GTF3C4 protein (Loxodonta africana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GTF3C4

General transcription factor IIIC subunit 4. (821 aa)

Predicted Functional Partners:

GTF3C5

0.961

GTF3C2

0.954

GTF3C3

0.949

GTF3C1

0.949

GTF3C6

0.896

BRF1

0.824

POLR3A

0.763

ZNF512

0.729

ZNF512B

0.729

BRF2

0.694

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRF1	BRF2	ENSLAFP00000001803	ENSLAFP00000026261	BRF1 RNA polymerase III transcription initiation factor subunit.	BRF2 RNA polymerase III transcription initiation factor subunit.	0.578
BRF1	GTF3C1	ENSLAFP00000001803	ENSLAFP00000018389	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 1.	0.912
BRF1	GTF3C2	ENSLAFP00000001803	ENSLAFP00000012036	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 2.	0.672
BRF1	GTF3C3	ENSLAFP00000001803	ENSLAFP00000001498	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 3.	0.995
BRF1	GTF3C4	ENSLAFP00000001803	ENSLAFP00000012898	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 4.	0.824
BRF1	GTF3C5	ENSLAFP00000001803	ENSLAFP00000002546	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 5.	0.850
BRF1	GTF3C6	ENSLAFP00000001803	ENSLAFP00000004207	BRF1 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 6.	0.597
BRF1	POLR3A	ENSLAFP00000001803	ENSLAFP00000014034	BRF1 RNA polymerase III transcription initiation factor subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.972
BRF1	ZNF512	ENSLAFP00000001803	ENSLAFP00000009351	BRF1 RNA polymerase III transcription initiation factor subunit.	Zinc finger protein 512.	0.425
BRF1	ZNF512B	ENSLAFP00000001803	ENSLAFP00000020285	BRF1 RNA polymerase III transcription initiation factor subunit.	Zinc finger protein 512B.	0.425
BRF2	BRF1	ENSLAFP00000026261	ENSLAFP00000001803	BRF2 RNA polymerase III transcription initiation factor subunit.	BRF1 RNA polymerase III transcription initiation factor subunit.	0.578
BRF2	GTF3C1	ENSLAFP00000026261	ENSLAFP00000018389	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 1.	0.754
BRF2	GTF3C2	ENSLAFP00000026261	ENSLAFP00000012036	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 2.	0.441
BRF2	GTF3C3	ENSLAFP00000026261	ENSLAFP00000001498	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 3.	0.969
BRF2	GTF3C4	ENSLAFP00000026261	ENSLAFP00000012898	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 4.	0.694
BRF2	GTF3C5	ENSLAFP00000026261	ENSLAFP00000002546	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 5.	0.850
BRF2	GTF3C6	ENSLAFP00000026261	ENSLAFP00000004207	BRF2 RNA polymerase III transcription initiation factor subunit.	General transcription factor IIIC subunit 6.	0.554
BRF2	POLR3A	ENSLAFP00000026261	ENSLAFP00000014034	BRF2 RNA polymerase III transcription initiation factor subunit.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.910
GTF3C1	BRF1	ENSLAFP00000018389	ENSLAFP00000001803	General transcription factor IIIC subunit 1.	BRF1 RNA polymerase III transcription initiation factor subunit.	0.912
GTF3C1	BRF2	ENSLAFP00000018389	ENSLAFP00000026261	General transcription factor IIIC subunit 1.	BRF2 RNA polymerase III transcription initiation factor subunit.	0.754

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.909

expected number of edges:

12

PPI enrichment p-value:

0.000132

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 106

1.19

1.66

8.07e-09

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 247

0.86

0.95

6.02e-08

GO:1901566

Organonitrogen compound biosynthetic process

11 of 261

0.84

0.9

8.96e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 54

1.43

2.4

1.09e-09

GO:0019843

rRNA binding

7 of 41

1.44

2.06

2.97e-07

GO:0003676

Nucleic acid binding

8 of 320

0.61

0.43

0.0106

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044391

Ribosomal subunit

6 of 15

1.81

3.22

7.51e-09

GO:0015935

Small ribosomal subunit

4 of 6

2.04

2.74

1.71e-06

GO:0005840

Ribosome

9 of 56

1.42

2.43

2.68e-10

GO:0015934

Large ribosomal subunit

2 of 9

1.56

0.88

0.0146

GO:0005622

Intracellular anatomical structure

10 of 705

0.36

0.3

0.0057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:112

Ribosome

8 of 45

1.46

2.4

4.03e-09

CL:105

Ribosome, and Translation regulator activity

9 of 64

1.36

2.14

3.45e-09

CL:113

rRNA-binding, and Elongation factor

5 of 32

1.41

1.6

2.75e-05

CL:115

rRNA-binding

4 of 26

1.4

1.31

0.00042

CL:176

Ribosome

3 of 13

1.58

1.23

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gha03010

Ribosome

9 of 53

1.44

2.54

1.47e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044391

Ribosomal subunit

7 of 23

1.7

2.95

7.38e-09

GOCC:0022626

Cytosolic ribosome

6 of 19

1.71

2.72

8.47e-08

GOCC:0005840

Ribosome

8 of 43

1.48

2.42

7.38e-09

GOCC:0022627

Cytosolic small ribosomal subunit

4 of 13

1.7

1.91

3.93e-05

GOCC:0015934

Large ribosomal subunit

3 of 10

1.69

1.42

0.00088

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 56

1.42

2.4

4.93e-10

KW-0699

rRNA-binding

7 of 38

1.48

2.25

6.18e-08

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