SLIT2 protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SLIT2

Slit guidance ligand 2. (1522 aa)

Predicted Functional Partners:

ROBO1

0.979

ROBO4

0.904

ROBO2

0.799

G3UDW3_LOXAF

0.799

NRG4

0.660

ADGRL2

0.652

ADGRL1

0.639

ADGRL3

0.637

DAG1

0.607

ROBO3

0.594

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRL1	SLIT2	ENSLAFP00000012724	ENSLAFP00000014878	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Slit guidance ligand 2.	0.639
ADGRL2	SLIT2	ENSLAFP00000011062	ENSLAFP00000014878	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Slit guidance ligand 2.	0.652
ADGRL3	SLIT2	ENSLAFP00000008258	ENSLAFP00000014878	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Slit guidance ligand 2.	0.637
DAG1	SLIT2	ENSLAFP00000009234	ENSLAFP00000014878	Dystroglycan 1.	Slit guidance ligand 2.	0.607
G3UDW3_LOXAF	ROBO2	ENSLAFP00000026021	ENSLAFP00000003016	Ig-like domain-containing protein.	Roundabout guidance receptor 2.	0.900
G3UDW3_LOXAF	SLIT2	ENSLAFP00000026021	ENSLAFP00000014878	Ig-like domain-containing protein.	Slit guidance ligand 2.	0.799
NRG4	SLIT2	ENSLAFP00000016190	ENSLAFP00000014878	Neuregulin 4.	Slit guidance ligand 2.	0.660
ROBO1	SLIT2	ENSLAFP00000006431	ENSLAFP00000014878	Roundabout guidance receptor 1.	Slit guidance ligand 2.	0.979
ROBO2	G3UDW3_LOXAF	ENSLAFP00000003016	ENSLAFP00000026021	Roundabout guidance receptor 2.	Ig-like domain-containing protein.	0.900
ROBO2	SLIT2	ENSLAFP00000003016	ENSLAFP00000014878	Roundabout guidance receptor 2.	Slit guidance ligand 2.	0.799
ROBO3	SLIT2	ENSLAFP00000024352	ENSLAFP00000014878	Roundabout guidance receptor 3.	Slit guidance ligand 2.	0.594
ROBO4	SLIT2	ENSLAFP00000012225	ENSLAFP00000014878	Roundabout guidance receptor 4.	Slit guidance ligand 2.	0.904
SLIT2	ADGRL1	ENSLAFP00000014878	ENSLAFP00000012724	Slit guidance ligand 2.	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	0.639
SLIT2	ADGRL2	ENSLAFP00000014878	ENSLAFP00000011062	Slit guidance ligand 2.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.652
SLIT2	ADGRL3	ENSLAFP00000014878	ENSLAFP00000008258	Slit guidance ligand 2.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.637
SLIT2	DAG1	ENSLAFP00000014878	ENSLAFP00000009234	Slit guidance ligand 2.	Dystroglycan 1.	0.607
SLIT2	G3UDW3_LOXAF	ENSLAFP00000014878	ENSLAFP00000026021	Slit guidance ligand 2.	Ig-like domain-containing protein.	0.799
SLIT2	NRG4	ENSLAFP00000014878	ENSLAFP00000016190	Slit guidance ligand 2.	Neuregulin 4.	0.660
SLIT2	ROBO1	ENSLAFP00000014878	ENSLAFP00000006431	Slit guidance ligand 2.	Roundabout guidance receptor 1.	0.979
SLIT2	ROBO2	ENSLAFP00000014878	ENSLAFP00000003016	Slit guidance ligand 2.	Roundabout guidance receptor 2.	0.799

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.839

expected number of edges:

11

PPI enrichment p-value:

1.87e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007214

Gamma-aminobutyric acid signaling pathway

7 of 23

2.76

7.08

2.12e-14

GO:0071420

Cellular response to histamine

3 of 4

3.15

3.1

2.32e-06

GO:0051932

Synaptic transmission, GABAergic

3 of 20

2.46

2.15

9.13e-05

GO:0007267

Cell-cell signaling

8 of 639

1.38

2.0

8.39e-08

GO:0006811

Ion transport

8 of 1105

1.14

1.31

5.19e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004890

GABA-A receptor activity

7 of 19

2.85

7.69

1.87e-15

GO:0022851

GABA-gated chloride ion channel activity

6 of 15

2.88

6.7

2.15e-13

GO:0005231

Excitatory extracellular ligand-gated ion channel activity

7 of 57

2.37

5.88

4.38e-13

GO:1904315

Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

7 of 60

2.35

5.81

4.91e-13

GO:0005254

Chloride channel activity

7 of 75

2.25

5.47

1.07e-12

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1902711

GABA-A receptor complex

7 of 20

2.82

7.74

1.29e-15

GO:0034707

Chloride channel complex

7 of 45

2.47

6.42

6.47e-14

GO:0045211

Postsynaptic membrane

8 of 164

1.97

4.69

1.10e-12

GO:0032590

Dendrite membrane

3 of 29

2.29

2.27

4.32e-05

GO:0043005

Neuron projection

9 of 941

1.26

1.84

7.72e-09

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37124892

(2023) Gamma-Aminobutyric Acid Type A Receptor Subunit Delta (GABRD) Inhibits Breast Cancer Progression by Regulating the Cell Cycle.

6 of 16

2.85

5.69

1.97e-11

PMID:35198562

(2021) GABAergic System Dysfunction in Autism Spectrum Disorders.

6 of 35

2.51

4.71

5.92e-10

PMID:34069910

(2021) Transcription Landscape of the Early Developmental Biology in Pigs.

5 of 97

1.99

2.23

2.51e-05

PMID:27748445

(2016) Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development.

4 of 49

2.19

1.91

0.00020

PMID:37599823

(2023) Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1(--) mice.

4 of 61

2.1

1.76

0.00037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20285

GABA-A receptor complex

9 of 18

2.98

11.05

5.63e-22

CL:20287

GABA-gated chloride ion channel activity, and Kinesin associated protein

8 of 13

3.07

10.19

5.68e-20

CL:20292

Gamma-aminobutyric-acid A receptor, beta subunit, and Kinesin associated protein

4 of 5

3.18

4.56

4.81e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ecb04727

GABAergic synapse

11 of 82

2.41

10.11

2.41e-24

ecb05033

Nicotine addiction

7 of 35

2.58

7.14

4.22e-15

ecb05032

Morphine addiction

7 of 86

2.19

5.34

9.80e-13

ecb04723

Retrograde endocannabinoid signaling

7 of 137

1.99

4.41

1.69e-11

ecb04080

Neuroactive ligand-receptor interaction

7 of 316

1.62

2.83

4.07e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-977443

GABA receptor activation

7 of 70

2.28

5.32

3.82e-12

MAP-112314

Neurotransmitter receptors and postsynaptic signal transmission

8 of 205

1.87

4.1

1.38e-11

MAP-112315

Transmission across Chemical Synapses

8 of 275

1.74

3.51

9.13e-11

MAP-112316

Neuronal System

8 of 432

1.55

2.67

2.37e-09

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0003793

Pituicyte

2 of 4

2.98

1.43

0.0026

BTO:0000672

Hindbrain

3 of 166

1.54

0.83

0.0188

BTO:0001484

Nervous system

9 of 2755

0.79

0.64

0.0011

BTO:0000142

Brain

8 of 2529

0.78

0.6

0.0026

BTO:0000282

Head

9 of 3245

0.72

0.56

0.0022

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1902710

GABA receptor complex

5 of 15

2.8

5.01

3.88e-10

GOCC:1902711

GABA-A receptor complex

3 of 8

2.85

2.62

1.61e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 209

1.74

2.67

1.90e-07

KW-1015

Disulfide bond

6 of 1202

0.98

0.81

0.0013

KW-1003

Cell membrane

6 of 1281

0.95

0.77

0.0015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02932

Neurotransmitter-gated ion-channel transmembrane region

7 of 45

2.47

6.15

2.86e-13

PF02931

Neurotransmitter-gated ion-channel ligand binding domain

6 of 43

2.42

5.06

6.24e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006028

Gamma-aminobutyric acid A receptor/Glycine receptor alpha

7 of 24

2.74

7.1

1.75e-14

IPR006029

Neurotransmitter-gated ion-channel transmembrane domain

7 of 44

2.48

6.11

3.84e-13

IPR038050

Neuronal acetylcholine receptor

7 of 45

2.47

6.09

3.84e-13

IPR036719

Neurotransmitter-gated ion-channel transmembrane domain superfamily

7 of 45

2.47

6.09

3.84e-13

IPR006201

Neurotransmitter-gated ion-channel

7 of 46

2.46

6.07

3.84e-13

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About