STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)    
Predicted Functional Partners:
G3U1T9_LOXAF
Peptidase S1 domain-containing protein.
  
     0.527
MST1R
Macrophage stimulating 1 receptor.
    
  0.507
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
  0.507
G3SRR3_LOXAF
Peptidase S1 domain-containing protein.
  
0.437
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
 
 0.430
LOC100667382
Uncharacterized protein; Belongs to the peptidase C1 family.
 
   
 0.411
G3TUP8_LOXAF
Uncharacterized protein; Belongs to the peptidase C1 family.
 
   
 0.411
LOC100665585
Uncharacterized protein; Belongs to the peptidase C1 family.
 
   
 0.411
LOC100661985
Uncharacterized protein; Belongs to the peptidase C1 family.
 
   
 0.411
TMPRSS4
Transmembrane serine protease 4; Belongs to the peptidase S1 family.
  
 
 
0.404
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.