SPATA46 protein (Loxodonta africana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SPATA46

Spermatogenesis associated 46. (247 aa)

Predicted Functional Partners:

SSMEM1

0.683

SPACA1

0.642

TM9SF3

0.521

DPY19L1

0.459

ARMC2

0.456

AGBL5

0.452

SEPTIN12

0.447

SPATA20

0.442

SPATA3

0.441

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGBL5	ARMC2	ENSLAFP00000012203	ENSLAFP00000005007	ATP/GTP binding protein like 5.	Armadillo repeat containing 2.	0.442
AGBL5	SPATA46	ENSLAFP00000012203	ENSLAFP00000015475	ATP/GTP binding protein like 5.	Spermatogenesis associated 46.	0.452
ARMC2	AGBL5	ENSLAFP00000005007	ENSLAFP00000012203	Armadillo repeat containing 2.	ATP/GTP binding protein like 5.	0.442
ARMC2	SPATA46	ENSLAFP00000005007	ENSLAFP00000015475	Armadillo repeat containing 2.	Spermatogenesis associated 46.	0.456
DPY19L1	SPACA1	ENSLAFP00000006714	ENSLAFP00000001380	Dpy-19 like C-mannosyltransferase 1.	Sperm acrosome associated 1.	0.576
DPY19L1	SPATA3	ENSLAFP00000006714	ENSLAFP00000008686	Dpy-19 like C-mannosyltransferase 1.	Uncharacterized protein.	0.448
DPY19L1	SPATA46	ENSLAFP00000006714	ENSLAFP00000015475	Dpy-19 like C-mannosyltransferase 1.	Spermatogenesis associated 46.	0.459
SEPTIN12	SPATA46	ENSLAFP00000023516	ENSLAFP00000015475	Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Spermatogenesis associated 46.	0.447
SPACA1	DPY19L1	ENSLAFP00000001380	ENSLAFP00000006714	Sperm acrosome associated 1.	Dpy-19 like C-mannosyltransferase 1.	0.576
SPACA1	SPATA46	ENSLAFP00000001380	ENSLAFP00000015475	Sperm acrosome associated 1.	Spermatogenesis associated 46.	0.642
SPACA1	SSMEM1	ENSLAFP00000001380	ENSLAFP00000022473	Sperm acrosome associated 1.	Serine rich single-pass membrane protein 1.	0.685
SPATA20	SPATA3	ENSLAFP00000017668	ENSLAFP00000008686	Spermatogenesis-associated protein 20; May play a role in fertility regulation.	Uncharacterized protein.	0.441
SPATA20	SPATA46	ENSLAFP00000017668	ENSLAFP00000015475	Spermatogenesis-associated protein 20; May play a role in fertility regulation.	Spermatogenesis associated 46.	0.442
SPATA3	DPY19L1	ENSLAFP00000008686	ENSLAFP00000006714	Uncharacterized protein.	Dpy-19 like C-mannosyltransferase 1.	0.448
SPATA3	SPATA20	ENSLAFP00000008686	ENSLAFP00000017668	Uncharacterized protein.	Spermatogenesis-associated protein 20; May play a role in fertility regulation.	0.441
SPATA3	SPATA46	ENSLAFP00000008686	ENSLAFP00000015475	Uncharacterized protein.	Spermatogenesis associated 46.	0.441
SPATA46	AGBL5	ENSLAFP00000015475	ENSLAFP00000012203	Spermatogenesis associated 46.	ATP/GTP binding protein like 5.	0.452
SPATA46	ARMC2	ENSLAFP00000015475	ENSLAFP00000005007	Spermatogenesis associated 46.	Armadillo repeat containing 2.	0.456
SPATA46	DPY19L1	ENSLAFP00000015475	ENSLAFP00000006714	Spermatogenesis associated 46.	Dpy-19 like C-mannosyltransferase 1.	0.459
SPATA46	SEPTIN12	ENSLAFP00000015475	ENSLAFP00000023516	Spermatogenesis associated 46.	Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.447

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015979

Photosynthesis

11 of 117

1.66

4.0

1.23e-15

GO:0019684

Photosynthesis, light reaction

6 of 40

1.86

3.0

7.95e-08

GO:0009767

Photosynthetic electron transport chain

3 of 16

1.96

1.38

0.0019

GO:0042549

Photosystem II stabilization

2 of 3

2.51

1.16

0.0076

GO:0009772

Photosynthetic electron transport in photosystem II

2 of 8

2.08

0.93

0.0178

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046906

Tetrapyrrole binding

4 of 58

1.52

1.1

0.0036

GO:0009055

Electron transfer activity

4 of 71

1.43

1.04

0.0039

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009523

Photosystem II

11 of 29

2.26

8.75

1.49e-22

GO:0042651

Thylakoid membrane

11 of 127

1.62

3.94

1.24e-16

GO:0031676

Plasma membrane-derived thylakoid membrane

10 of 108

1.65

3.89

4.66e-15

GO:0009654

Photosystem II oxygen evolving complex

2 of 5

2.28

1.72

0.00056

GO:0009539

Photosystem II reaction center

2 of 6

2.21

1.65

0.00071

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4139

Photosystem II

11 of 18

2.47

10.15

1.57e-23

CL:4141

Photosystem II

7 of 12

2.45

6.31

9.31e-14

CL:4145

Photosystem II cytochrome b559, N-terminal, and Chlorophyll

3 of 5

2.46

2.32

4.34e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00195

Photosynthesis

11 of 73

1.86

5.54

9.98e-19

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009523

Photosystem II

9 of 28

2.19

6.57

2.06e-16

GOCC:0034357

Photosynthetic membrane

10 of 68

1.85

5.02

3.92e-16

GOCC:0030075

Bacterial thylakoid

3 of 24

1.78

1.52

0.00065

GOCC:0030096

Plasma membrane-derived thylakoid photosystem II

2 of 11

1.94

1.08

0.0083

GOCC:0016020

Membrane

11 of 738

0.86

0.95

1.92e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0604

Photosystem II

10 of 18

2.43

9.03

6.70e-21

KW-0793

Thylakoid

10 of 79

1.78

4.64

8.56e-16

KW-0674

Reaction center

2 of 5

2.28

1.37

0.0027

KW-0148

Chlorophyll

2 of 6

2.21

1.36

0.0027

KW-0249

Electron transport

3 of 40

1.56

1.16

0.0027

(more ...)

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