STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HBB/DHemoglobin subunit delta; Belongs to the globin family. (147 aa)    
Predicted Functional Partners:
HBA
Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.
  
0.999
HBQ1
Hemoglobin subunit theta 1; Belongs to the globin family.
  
0.955
LOC100658044
Globin E1; Belongs to the globin family.
  
0.915
LOC100657757
GLOBIN domain-containing protein; Belongs to the globin family.
   
0.913
G3TGU5_LOXAF
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
   
 0.906
APOB
Apolipoprotein B.
   
 
 0.692
THPO
Thrombopoietin.
      
 0.688
AHSP
Alpha hemoglobin stabilizing protein.
   
 
 0.628
CYB5R4
Cytochrome b5 reductase 4.
   
 0.627
MASP1
Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family.
   
 0.613
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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