LRFN2 protein (Loxodonta africana) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

LRFN2

Leucine rich repeat and fibronectin type III domain containing 2. (790 aa)

Predicted Functional Partners:

DLG4

0.781

DLG3

0.732

ADGRL3

0.658

ADGRL2

0.658

ADGRL1

0.658

GRIN1

0.652

GP9

0.574

PRTG

0.560

GRIN2D

0.545

LRFN1

0.521

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRL1	GP9	ENSLAFP00000012724	ENSLAFP00000029200	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Glycoprotein IX platelet.	0.658
ADGRL1	LRFN1	ENSLAFP00000012724	ENSLAFP00000003948	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 1.	0.658
ADGRL1	LRFN2	ENSLAFP00000012724	ENSLAFP00000016830	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 2.	0.658
ADGRL2	GP9	ENSLAFP00000011062	ENSLAFP00000029200	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Glycoprotein IX platelet.	0.658
ADGRL2	LRFN1	ENSLAFP00000011062	ENSLAFP00000003948	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 1.	0.658
ADGRL2	LRFN2	ENSLAFP00000011062	ENSLAFP00000016830	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 2.	0.658
ADGRL3	GP9	ENSLAFP00000008258	ENSLAFP00000029200	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Glycoprotein IX platelet.	0.658
ADGRL3	LRFN1	ENSLAFP00000008258	ENSLAFP00000003948	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 1.	0.658
ADGRL3	LRFN2	ENSLAFP00000008258	ENSLAFP00000016830	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and fibronectin type III domain containing 2.	0.658
DLG3	DLG4	ENSLAFP00000000209	ENSLAFP00000015624	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.930
DLG3	GRIN1	ENSLAFP00000000209	ENSLAFP00000028680	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	ANF_receptor domain-containing protein.	0.805
DLG3	GRIN2D	ENSLAFP00000000209	ENSLAFP00000000600	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.685
DLG3	LRFN1	ENSLAFP00000000209	ENSLAFP00000003948	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Leucine rich repeat and fibronectin type III domain containing 1.	0.456
DLG3	LRFN2	ENSLAFP00000000209	ENSLAFP00000016830	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Leucine rich repeat and fibronectin type III domain containing 2.	0.732
DLG4	DLG3	ENSLAFP00000015624	ENSLAFP00000000209	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.930
DLG4	GRIN1	ENSLAFP00000015624	ENSLAFP00000028680	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	ANF_receptor domain-containing protein.	0.997
DLG4	GRIN2D	ENSLAFP00000015624	ENSLAFP00000000600	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.958
DLG4	LRFN1	ENSLAFP00000015624	ENSLAFP00000003948	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Leucine rich repeat and fibronectin type III domain containing 1.	0.609
DLG4	LRFN2	ENSLAFP00000015624	ENSLAFP00000016830	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Leucine rich repeat and fibronectin type III domain containing 2.	0.781
GP9	ADGRL1	ENSLAFP00000029200	ENSLAFP00000012724	Glycoprotein IX platelet.	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	0.658

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.913

expected number of edges:

10

PPI enrichment p-value:

1.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 22

1.85

2.85

2.11e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 22

1.85

2.94

1.12e-07

GO:0002161

aminoacyl-tRNA editing activity

2 of 6

1.94

0.9

0.0193

GO:0005524

ATP binding

6 of 271

0.76

0.49

0.0171

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:332

Aminoacyl-tRNA biosynthesis

5 of 20

1.81

2.41

3.00e-06

CL:335

tRNA aminoacylation

4 of 12

1.94

2.24

1.83e-05

CL:478

Mixed, incl. Phosphoesterase MJ0912, and Threonyl/alanyl tRNA synthetase, SAD

3 of 6

2.12

1.88

0.00021

CL:129

Mixed, incl. Translation, and ATP-dependent activity

10 of 190

1.14

1.53

1.35e-08

CL:136

Translation, and Protein export

7 of 118

1.19

1.35

1.09e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fsc00970

Aminoacyl-tRNA biosynthesis

7 of 24

1.88

3.79

2.56e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

7 of 22

1.92

3.87

2.79e-10

KW-0648

Protein biosynthesis

7 of 43

1.63

2.81

5.80e-09

KW-0436

Ligase

8 of 58

1.56

2.79

6.95e-10

KW-0820

tRNA-binding

4 of 15

1.84

2.24

1.12e-05

KW-0963

Cytoplasm

8 of 169

1.09

1.29

1.11e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01588

Putative tRNA binding domain

2 of 2

2.42

0.82

0.0321

PF00133

tRNA synthetases class I (I, L, M and V)

2 of 2

2.42

0.82

0.0321

PF08264

Anticodon-binding domain of tRNA ligase

2 of 3

2.24

0.81

0.0321

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

4 of 12

1.94

1.79

0.00022

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 7

2.05

1.34

0.0026

IPR018163

Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily

2 of 2

2.42

0.85

0.0284

IPR012947

Threonyl/alanyl tRNA synthetase, SAD

2 of 2

2.42

0.85

0.0284

IPR002547

tRNA-binding domain

2 of 2

2.42

0.85

0.0284

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.42

1.18

0.0068

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