STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIK3SIK family kinase 3. (1362 aa)    
Predicted Functional Partners:
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      
 0.666
COL2A1
Collagen type II alpha 1 chain.
    
 0.644
THRA
Thyroid hormone receptor alpha.
    
 
 0.580
MCM2
DNA helicase; Belongs to the MCM family.
   
 
 0.579
DMBX1
Diencephalon/mesencephalon homeobox 1.
      
 0.526
TAZ
Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism.
      
 0.509
SCGN
Secretagogin, EF-hand calcium binding protein.
   
 0.501
MAGI3
Membrane associated guanylate kinase, WW and PDZ domain containing 3.
   
 0.491
ZFP64
ZFP64 zinc finger protein.
   
 
 0.452
YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.
    
 0.421
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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