DMRTC2 protein (Loxodonta africana) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

DMRTC2

DMRT like family C2. (412 aa)

Predicted Functional Partners:

ITFG2

0.892

KPTN

0.881

DEPDC5

0.835

WDR59

0.821

WDR24

0.817

NPRL2

0.814

RPS19

0.661

LYPD4

0.630

NPRL3

0.595

MIOS

0.529

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEPDC5	DMRTC2	ENSLAFP00000010258	ENSLAFP00000018306	DEP domain-containing protein.	DMRT like family C2.	0.835
DEPDC5	ITFG2	ENSLAFP00000010258	ENSLAFP00000019241	DEP domain-containing protein.	Integrin alpha FG-GAP repeat containing 2.	0.982
DEPDC5	KPTN	ENSLAFP00000010258	ENSLAFP00000007777	DEP domain-containing protein.	Kaptin, actin binding protein.	0.976
DEPDC5	MIOS	ENSLAFP00000010258	ENSLAFP00000004259	DEP domain-containing protein.	Meiosis regulator for oocyte development.	0.999
DEPDC5	NPRL2	ENSLAFP00000010258	ENSLAFP00000001599	DEP domain-containing protein.	NPR2 like, GATOR1 complex subunit.	0.999
DEPDC5	NPRL3	ENSLAFP00000010258	ENSLAFP00000022568	DEP domain-containing protein.	NPR3 like, GATOR1 complex subunit.	0.999
DEPDC5	WDR24	ENSLAFP00000010258	ENSLAFP00000012008	DEP domain-containing protein.	WD repeat domain 24.	0.999
DEPDC5	WDR59	ENSLAFP00000010258	ENSLAFP00000019664	DEP domain-containing protein.	WD repeat domain 59.	0.999
DMRTC2	DEPDC5	ENSLAFP00000018306	ENSLAFP00000010258	DMRT like family C2.	DEP domain-containing protein.	0.835
DMRTC2	ITFG2	ENSLAFP00000018306	ENSLAFP00000019241	DMRT like family C2.	Integrin alpha FG-GAP repeat containing 2.	0.892
DMRTC2	KPTN	ENSLAFP00000018306	ENSLAFP00000007777	DMRT like family C2.	Kaptin, actin binding protein.	0.881
DMRTC2	LYPD4	ENSLAFP00000018306	ENSLAFP00000016750	DMRT like family C2.	LY6/PLAUR domain containing 4.	0.630
DMRTC2	MIOS	ENSLAFP00000018306	ENSLAFP00000004259	DMRT like family C2.	Meiosis regulator for oocyte development.	0.529
DMRTC2	NPRL2	ENSLAFP00000018306	ENSLAFP00000001599	DMRT like family C2.	NPR2 like, GATOR1 complex subunit.	0.814
DMRTC2	NPRL3	ENSLAFP00000018306	ENSLAFP00000022568	DMRT like family C2.	NPR3 like, GATOR1 complex subunit.	0.595
DMRTC2	RPS19	ENSLAFP00000018306	ENSLAFP00000000538	DMRT like family C2.	Ribosomal protein S19.	0.661
DMRTC2	WDR24	ENSLAFP00000018306	ENSLAFP00000012008	DMRT like family C2.	WD repeat domain 24.	0.817
DMRTC2	WDR59	ENSLAFP00000018306	ENSLAFP00000019664	DMRT like family C2.	WD repeat domain 59.	0.821
ITFG2	DEPDC5	ENSLAFP00000019241	ENSLAFP00000010258	Integrin alpha FG-GAP repeat containing 2.	DEP domain-containing protein.	0.982
ITFG2	DMRTC2	ENSLAFP00000019241	ENSLAFP00000018306	Integrin alpha FG-GAP repeat containing 2.	DMRT like family C2.	0.892

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

4

PPI enrichment p-value:

0.687

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042777

Proton motive force-driven plasma membrane ATP synthesis

4 of 5

2.25

2.9

1.83e-06

GO:0015986

Proton motive force-driven ATP synthesis

5 of 13

1.94

2.81

6.06e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

9 of 19

2.03

5.37

2.10e-14

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

7 of 9

2.24

5.17

5.89e-12

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

6 of 14

1.98

3.71

2.44e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016469

Proton-transporting two-sector ATPase complex

9 of 17

2.07

5.87

1.54e-15

GO:0033176

Proton-transporting V-type ATPase complex

5 of 5

2.35

4.16

4.28e-09

GO:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

4 of 7

2.11

2.87

1.18e-06

GO:0033179

Proton-transporting V-type ATPase, V0 domain

3 of 3

2.35

2.47

1.86e-05

GO:0045259

Proton-transporting ATP synthase complex

3 of 11

1.79

1.67

0.00028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1566

ATPase-coupled ion transmembrane transporter activity, and ATP synthase subunit C

11 of 11

2.35

9.0

7.69e-22

CL:1570

ATPase-coupled ion transmembrane transporter activity

6 of 6

2.35

4.85

1.09e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 36

1.75

3.99

4.95e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

8 of 23

1.89

4.51

5.86e-13

MAP-168256

Immune System

8 of 26

1.84

4.3

6.73e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016469

Proton-transporting two-sector ATPase complex

8 of 20

1.95

4.53

2.81e-12

GOCC:0033176

Proton-transporting V-type ATPase complex

5 of 8

2.15

3.48

4.90e-08

GOCC:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

3 of 10

1.83

1.56

0.00059

GOCC:0033179

Proton-transporting V-type ATPase, V0 domain

2 of 5

1.95

1.03

0.0103

GOCC:0005773

Vacuole

2 of 5

1.95

1.03

0.0103

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 18

1.7

1.62

0.00026

KW-0375

Hydrogen ion transport

3 of 11

1.79

1.32

0.0020

KW-0066

ATP synthesis

3 of 11

1.79

1.32

0.0020

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