G3TRX7_LOXAF protein (Loxodonta africana) - STRING interaction network

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G3TRX7_LOXAF

Histone H2A; Belongs to the histone H2A family. (115 aa)

Predicted Functional Partners:

MYSM1

0.673

G3U8T3_LOXAF

0.573

ENSLAFP00000028190

0.573

G3UKU6_LOXAF

0.573

LOC100665018

0.546

LOC100675119

0.541

UBA52

0.509

LOC100675676

0.487

ENSLAFP00000019204

0.487

ATM

0.482

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ENSLAFP00000028190	ENSLAFP00000006871	ENSLAFP00000028190	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.563
ATM	G3TRX7_LOXAF	ENSLAFP00000006871	ENSLAFP00000018335	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2A; Belongs to the histone H2A family.	0.482
ATM	G3U8T3_LOXAF	ENSLAFP00000006871	ENSLAFP00000024241	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.563
ATM	G3UKU6_LOXAF	ENSLAFP00000006871	ENSLAFP00000028455	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.563
ATM	MYSM1	ENSLAFP00000006871	ENSLAFP00000003219	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Myb like, SWIRM and MPN domains 1.	0.428
ATM	UBA52	ENSLAFP00000006871	ENSLAFP00000017811	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.735
ENSLAFP00000019204	ENSLAFP00000028190	ENSLAFP00000019204	ENSLAFP00000028190	annotation not available	annotation not available	0.444
ENSLAFP00000019204	G3TRX7_LOXAF	ENSLAFP00000019204	ENSLAFP00000018335	annotation not available	Histone H2A; Belongs to the histone H2A family.	0.487
ENSLAFP00000019204	G3U8T3_LOXAF	ENSLAFP00000019204	ENSLAFP00000024241	annotation not available	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.444
ENSLAFP00000019204	G3UKU6_LOXAF	ENSLAFP00000019204	ENSLAFP00000028455	annotation not available	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.444
ENSLAFP00000019204	UBA52	ENSLAFP00000019204	ENSLAFP00000017811	annotation not available	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.501
ENSLAFP00000028190	ATM	ENSLAFP00000028190	ENSLAFP00000006871	annotation not available	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.563
ENSLAFP00000028190	ENSLAFP00000019204	ENSLAFP00000028190	ENSLAFP00000019204	annotation not available	annotation not available	0.444
ENSLAFP00000028190	G3TRX7_LOXAF	ENSLAFP00000028190	ENSLAFP00000018335	annotation not available	Histone H2A; Belongs to the histone H2A family.	0.573
ENSLAFP00000028190	G3U8T3_LOXAF	ENSLAFP00000028190	ENSLAFP00000024241	annotation not available	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.801
ENSLAFP00000028190	G3UKU6_LOXAF	ENSLAFP00000028190	ENSLAFP00000028455	annotation not available	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.801
ENSLAFP00000028190	LOC100665018	ENSLAFP00000028190	ENSLAFP00000024137	annotation not available	Histone domain-containing protein; Belongs to the histone H2B family.	0.572
ENSLAFP00000028190	LOC100675119	ENSLAFP00000028190	ENSLAFP00000009354	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.572
ENSLAFP00000028190	LOC100675676	ENSLAFP00000028190	ENSLAFP00000018651	annotation not available	Histone domain-containing protein; Belongs to the histone H2B family.	0.444
ENSLAFP00000028190	MYSM1	ENSLAFP00000028190	ENSLAFP00000003219	annotation not available	Myb like, SWIRM and MPN domains 1.	0.575

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