G3TSL6_LOXAF protein (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

G3TSL6_LOXAF

G_PROTEIN_RECEP_F3_4 domain-containing protein. (202 aa)

Predicted Functional Partners:

G3TYV2_LOXAF

0.748

TAS1R2

0.524

G3TC70_LOXAF

0.497

BGLAP

0.456

GPR156

0.409

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGLAP	G3TSL6_LOXAF	ENSLAFP00000014103	ENSLAFP00000018574	Osteocalcin; Binds strongly to apatite and calcium.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.456
G3TC70_LOXAF	G3TSL6_LOXAF	ENSLAFP00000011627	ENSLAFP00000018574	Uncharacterized protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.497
G3TC70_LOXAF	G3TYV2_LOXAF	ENSLAFP00000011627	ENSLAFP00000020760	Uncharacterized protein.	ANF_receptor domain-containing protein.	0.497
G3TC70_LOXAF	TAS1R2	ENSLAFP00000011627	ENSLAFP00000020876	Uncharacterized protein.	Taste 1 receptor member 2.	0.497
G3TSL6_LOXAF	BGLAP	ENSLAFP00000018574	ENSLAFP00000014103	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Osteocalcin; Binds strongly to apatite and calcium.	0.456
G3TSL6_LOXAF	G3TC70_LOXAF	ENSLAFP00000018574	ENSLAFP00000011627	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Uncharacterized protein.	0.497
G3TSL6_LOXAF	G3TYV2_LOXAF	ENSLAFP00000018574	ENSLAFP00000020760	G_PROTEIN_RECEP_F3_4 domain-containing protein.	ANF_receptor domain-containing protein.	0.748
G3TSL6_LOXAF	GPR156	ENSLAFP00000018574	ENSLAFP00000011411	G_PROTEIN_RECEP_F3_4 domain-containing protein.	G protein-coupled receptor 156.	0.409
G3TSL6_LOXAF	TAS1R2	ENSLAFP00000018574	ENSLAFP00000020876	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Taste 1 receptor member 2.	0.524
G3TYV2_LOXAF	G3TC70_LOXAF	ENSLAFP00000020760	ENSLAFP00000011627	ANF_receptor domain-containing protein.	Uncharacterized protein.	0.497
G3TYV2_LOXAF	G3TSL6_LOXAF	ENSLAFP00000020760	ENSLAFP00000018574	ANF_receptor domain-containing protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.748
GPR156	G3TSL6_LOXAF	ENSLAFP00000011411	ENSLAFP00000018574	G protein-coupled receptor 156.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.409
TAS1R2	G3TC70_LOXAF	ENSLAFP00000020876	ENSLAFP00000011627	Taste 1 receptor member 2.	Uncharacterized protein.	0.497
TAS1R2	G3TSL6_LOXAF	ENSLAFP00000020876	ENSLAFP00000018574	Taste 1 receptor member 2.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.524

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

4

PPI enrichment p-value:

0.687

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042777

Proton motive force-driven plasma membrane ATP synthesis

4 of 5

2.25

2.9

1.83e-06

GO:0015986

Proton motive force-driven ATP synthesis

5 of 13

1.94

2.81

6.06e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

9 of 19

2.03

5.37

2.10e-14

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

7 of 9

2.24

5.17

5.89e-12

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

6 of 14

1.98

3.71

2.44e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016469

Proton-transporting two-sector ATPase complex

9 of 17

2.07

5.87

1.54e-15

GO:0033176

Proton-transporting V-type ATPase complex

5 of 5

2.35

4.16

4.28e-09

GO:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

4 of 7

2.11

2.87

1.18e-06

GO:0033179

Proton-transporting V-type ATPase, V0 domain

3 of 3

2.35

2.47

1.86e-05

GO:0045259

Proton-transporting ATP synthase complex

3 of 11

1.79

1.67

0.00028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1566

ATPase-coupled ion transmembrane transporter activity, and ATP synthase subunit C

11 of 11

2.35

9.0

7.69e-22

CL:1570

ATPase-coupled ion transmembrane transporter activity

6 of 6

2.35

4.85

1.09e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 36

1.75

3.99

4.95e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

8 of 23

1.89

4.51

5.86e-13

MAP-168256

Immune System

8 of 26

1.84

4.3

6.73e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016469

Proton-transporting two-sector ATPase complex

8 of 20

1.95

4.53

2.81e-12

GOCC:0033176

Proton-transporting V-type ATPase complex

5 of 8

2.15

3.48

4.90e-08

GOCC:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

3 of 10

1.83

1.56

0.00059

GOCC:0033179

Proton-transporting V-type ATPase, V0 domain

2 of 5

1.95

1.03

0.0103

GOCC:0005773

Vacuole

2 of 5

1.95

1.03

0.0103

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 18

1.7

1.62

0.00026

KW-0375

Hydrogen ion transport

3 of 11

1.79

1.32

0.0020

KW-0066

ATP synthesis

3 of 11

1.79

1.32

0.0020

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About