STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AIF1Allograft inflammatory factor 1. (140 aa)    
Predicted Functional Partners:
TYROBP
TYRO protein tyrosine kinase binding protein.
   
  
 0.848
FCER1G
Fc fragment of IgE receptor Ig.
   
  
 0.669
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
    
 0.652
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
    
 0.610
CCR8
C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family.
   
 0.607
ITGB2
Integrin beta.
   
 
 0.578
RBFOX3
RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events.
   
 
 0.568
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
  
 0.562
CD68
CD68 molecule.
   
 
 0.549
G3TC70_LOXAF
Uncharacterized protein.
   
 0.525
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.