AR protein (Loxodonta africana) - STRING interaction network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	HSP90AA1	ENSLAFP00000020342	ENSLAFP00000025294	Androgen receptor.	HATPase_c domain-containing protein.	0.971
AR	HSP90AB1	ENSLAFP00000020342	ENSLAFP00000019545	Androgen receptor.	Heat shock protein 90 alpha family class B member 1.	0.971
AR	HSP90B1	ENSLAFP00000020342	ENSLAFP00000013455	Androgen receptor.	Heat shock protein 90 beta family member 1.	0.938
AR	MDM2	ENSLAFP00000020342	ENSLAFP00000004935	Androgen receptor.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.943
AR	NCOA2	ENSLAFP00000020342	ENSLAFP00000007644	Androgen receptor.	Nuclear receptor coactivator.	0.959
AR	NCOA3	ENSLAFP00000020342	ENSLAFP00000000544	Androgen receptor.	Nuclear receptor coactivator.	0.941
AR	NCOA4	ENSLAFP00000020342	ENSLAFP00000000728	Androgen receptor.	Nuclear receptor coactivator 4.	0.958
AR	NCOR1	ENSLAFP00000020342	ENSLAFP00000028513	Androgen receptor.	Nuclear receptor corepressor 1.	0.896
AR	PRKACA	ENSLAFP00000020342	ENSLAFP00000020656	Androgen receptor.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.909
AR	PRKACB	ENSLAFP00000020342	ENSLAFP00000005492	Androgen receptor.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.909
HSP90AA1	AR	ENSLAFP00000025294	ENSLAFP00000020342	HATPase_c domain-containing protein.	Androgen receptor.	0.971
HSP90AA1	HSP90AB1	ENSLAFP00000025294	ENSLAFP00000019545	HATPase_c domain-containing protein.	Heat shock protein 90 alpha family class B member 1.	0.900
HSP90AA1	HSP90B1	ENSLAFP00000025294	ENSLAFP00000013455	HATPase_c domain-containing protein.	Heat shock protein 90 beta family member 1.	0.927
HSP90AB1	AR	ENSLAFP00000019545	ENSLAFP00000020342	Heat shock protein 90 alpha family class B member 1.	Androgen receptor.	0.971
HSP90AB1	HSP90AA1	ENSLAFP00000019545	ENSLAFP00000025294	Heat shock protein 90 alpha family class B member 1.	HATPase_c domain-containing protein.	0.900
HSP90AB1	HSP90B1	ENSLAFP00000019545	ENSLAFP00000013455	Heat shock protein 90 alpha family class B member 1.	Heat shock protein 90 beta family member 1.	0.927
HSP90B1	AR	ENSLAFP00000013455	ENSLAFP00000020342	Heat shock protein 90 beta family member 1.	Androgen receptor.	0.938
HSP90B1	HSP90AA1	ENSLAFP00000013455	ENSLAFP00000025294	Heat shock protein 90 beta family member 1.	HATPase_c domain-containing protein.	0.927
HSP90B1	HSP90AB1	ENSLAFP00000013455	ENSLAFP00000019545	Heat shock protein 90 beta family member 1.	Heat shock protein 90 alpha family class B member 1.	0.927
MDM2	AR	ENSLAFP00000004935	ENSLAFP00000020342	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Androgen receptor.	0.943

page 1 of 2

Network Stats

number of nodes:

number of edges:

average node degree:

7.82

avg. local clustering coefficient:

0.908

expected number of edges:

PPI enrichment p-value:

5.96e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050853

B cell receptor signaling pathway

8 of 78

2.27

5.85

1.47e-13

GO:0030183

B cell differentiation

7 of 94

2.13

4.68

2.97e-11

GO:1903131

Mononuclear cell differentiation

9 of 234

1.85

4.25

1.44e-12

GO:0030098

Lymphocyte differentiation

8 of 208

1.85

3.94

2.97e-11

GO:0050778

Positive regulation of immune response

9 of 380

1.63

3.26

2.97e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051219

Phosphoprotein binding

5 of 82

2.05

2.74

1.85e-06

GO:0140031

Phosphorylation-dependent protein binding

3 of 5

3.04

2.74

1.02e-05

GO:0001784

Phosphotyrosine residue binding

4 of 43

2.23

2.54

1.02e-05

GO:0043274

Phospholipase binding

3 of 17

2.51

2.19

8.31e-05

GO:0004715

Non-membrane spanning protein tyrosine kinase activity

3 of 42

2.11

1.59

0.00086

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019815

B cell receptor complex

3 of 3

3.26

3.0

3.81e-06

GO:0098802

Plasma membrane signaling receptor complex

4 of 140

1.72

1.49

0.00063

GO:0045121

Membrane raft

4 of 202

1.56

1.28

0.0013

GO:0098797

Plasma membrane protein complex

5 of 456

1.3

1.09

0.0013

GO:0098552

Side of membrane

5 of 468

1.29

1.08

0.0013

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13329

Mixed, incl. Regulation of signaling by CBL, and DAP12 signaling

7 of 40

2.5

6.17

3.40e-13

CL:13330

GPVI-mediated activation cascade, and Zinc finger, Btk motif

6 of 24

2.66

5.9

3.56e-12

CL:13335

Vav, PH domain, and PLC-gamma, C-terminal SH2 domain

3 of 5

3.04

3.01

3.25e-06

CL:25080

Mixed, incl. B-cell antigen receptor complex-associated protein alpha/beta chain, and Calcium ion import into cytosol

2 of 6

2.78

1.39

0.0030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav04662

B cell receptor signaling pathway

8 of 57

2.41

7.17

4.25e-16

lav04664

Fc epsilon RI signaling pathway

6 of 55

2.3

4.93

4.68e-11

lav04650

Natural killer cell mediated cytotoxicity

4 of 75

1.99

2.43

7.99e-06

lav04666

Fc gamma R-mediated phagocytosis

4 of 78

1.97

2.41

7.99e-06

lav04064

NF-kappa B signaling pathway

4 of 79

1.96

2.41

7.99e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983695

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

10 of 192

1.98

5.77

8.01e-17

MAP-983705

Signaling by the B Cell Receptor (BCR)

11 of 278

1.86

5.37

7.88e-18

MAP-912631

Regulation of signaling by CBL

5 of 20

2.66

4.92

3.86e-10

MAP-512988

Interleukin-3, Interleukin-5 and GM-CSF signaling

5 of 47

2.29

3.86

1.50e-08

MAP-2424491

DAP12 signaling

4 of 33

2.34

3.18

6.07e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0019815

B cell receptor complex

3 of 6

2.96

2.62

1.70e-05

GOCC:0098802

Plasma membrane signaling receptor complex

4 of 162

1.65

1.34

0.0012

GOCC:0098797

Plasma membrane protein complex

5 of 429

1.33

1.12

0.0012

GOCC:0098796

Membrane protein complex

6 of 911

1.08

0.89

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

7 of 98

2.11

4.81

9.94e-12

KW-0728

SH3 domain

6 of 201

1.74

2.76

8.66e-08

KW-0829

Tyrosine-protein kinase

3 of 69

1.9

1.53

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000980

SH2 domain

7 of 101

2.1

4.3

2.39e-10

IPR036860

SH2 domain superfamily

7 of 106

2.08

4.25

2.39e-10

IPR036028

SH3-like domain superfamily

6 of 196

1.75

2.48

9.77e-07

IPR001452

SH3 domain

6 of 204

1.73

2.45

9.77e-07

IPR039695

B-cell antigen receptor complex-associated protein alpha/beta chain

2 of 2

3.26

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

7 of 102

2.1

4.6

2.96e-11

SM00326

Src homology 3 domains

5 of 193

1.67

2.01

1.56e-05

SM00077

Immunoreceptor tyrosine-based activation motif

2 of 6

2.78

1.48

0.0020

SM00219

Tyrosine kinase, catalytic domain

3 of 82

1.82

1.3

0.0023

SM00233

Pleckstrin homology domain.

3 of 245

1.35

0.63

0.0453

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