CENPF protein (Loxodonta africana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

CENPF

Centromere protein F. (2833 aa)

Predicted Functional Partners:

BUB1B

0.976

CENPE

0.965

BUB1

0.952

NDC80

0.929

KIF2C

0.914

DLGAP5

0.913

CDK1

0.905

KIF11

0.903

ESPL1

0.901

TOP2A

0.901

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUB1	BUB1B	ENSLAFP00000007193	ENSLAFP00000009774	BUB1 mitotic checkpoint serine/threonine kinase.	Uncharacterized protein.	0.995
BUB1	CDK1	ENSLAFP00000007193	ENSLAFP00000025378	BUB1 mitotic checkpoint serine/threonine kinase.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.967
BUB1	CENPE	ENSLAFP00000007193	ENSLAFP00000015033	BUB1 mitotic checkpoint serine/threonine kinase.	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.957
BUB1	CENPF	ENSLAFP00000007193	ENSLAFP00000020570	BUB1 mitotic checkpoint serine/threonine kinase.	Centromere protein F.	0.952
BUB1	DLGAP5	ENSLAFP00000007193	ENSLAFP00000022094	BUB1 mitotic checkpoint serine/threonine kinase.	DLG associated protein 5.	0.949
BUB1	ESPL1	ENSLAFP00000007193	ENSLAFP00000007004	BUB1 mitotic checkpoint serine/threonine kinase.	Extra spindle pole bodies like 1, separase.	0.942
BUB1	KIF11	ENSLAFP00000007193	ENSLAFP00000012955	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.938
BUB1	KIF2C	ENSLAFP00000007193	ENSLAFP00000003315	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.953
BUB1	NDC80	ENSLAFP00000007193	ENSLAFP00000003759	BUB1 mitotic checkpoint serine/threonine kinase.	NDC80 kinetochore complex component.	0.985
BUB1	TOP2A	ENSLAFP00000007193	ENSLAFP00000027558	BUB1 mitotic checkpoint serine/threonine kinase.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.899
BUB1B	BUB1	ENSLAFP00000009774	ENSLAFP00000007193	Uncharacterized protein.	BUB1 mitotic checkpoint serine/threonine kinase.	0.995
BUB1B	CDK1	ENSLAFP00000009774	ENSLAFP00000025378	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.972
BUB1B	CENPE	ENSLAFP00000009774	ENSLAFP00000015033	Uncharacterized protein.	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.985
BUB1B	CENPF	ENSLAFP00000009774	ENSLAFP00000020570	Uncharacterized protein.	Centromere protein F.	0.976
BUB1B	DLGAP5	ENSLAFP00000009774	ENSLAFP00000022094	Uncharacterized protein.	DLG associated protein 5.	0.919
BUB1B	ESPL1	ENSLAFP00000009774	ENSLAFP00000007004	Uncharacterized protein.	Extra spindle pole bodies like 1, separase.	0.962
BUB1B	KIF11	ENSLAFP00000009774	ENSLAFP00000012955	Uncharacterized protein.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.963
BUB1B	KIF2C	ENSLAFP00000009774	ENSLAFP00000003315	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.943
BUB1B	NDC80	ENSLAFP00000009774	ENSLAFP00000003759	Uncharacterized protein.	NDC80 kinetochore complex component.	0.982
BUB1B	TOP2A	ENSLAFP00000009774	ENSLAFP00000027558	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.916

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Network Stats

number of nodes:

7

number of edges:

20

average node degree:

5.71

avg. local clustering coefficient:

0.952

expected number of edges:

7

PPI enrichment p-value:

2.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006537

Glutamate biosynthetic process

3 of 3

2.35

1.56

0.0012

GO:0044205

De novo UMP biosynthetic process

3 of 9

1.87

1.4

0.0015

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006221

Pyrimidine nucleotide biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

2 of 4

2.05

1.03

0.0113

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

8 of 129

1.14

1.31

5.49e-06

GO:0051536

Iron-sulfur cluster binding

5 of 58

1.29

1.11

0.00099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:666

Ribonucleoside monophosphate biosynthetic process, and Nitrogen metabolism

7 of 36

1.64

2.63

5.16e-08

CL:696

De novo UMP biosynthetic process

3 of 10

1.83

1.39

0.0015

CL:661

Carboxylic acid metabolic process, and Ribonucleoside monophosphate metabolic process

9 of 199

1.01

1.13

1.60e-06

CL:699

De novo UMP biosynthetic process

2 of 5

1.95

0.86

0.0237

CL:718

Nitrogen metabolism

2 of 7

1.81

0.75

0.0364

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.55

1.42

0.00047

map00910

Nitrogen metabolism

3 of 13

1.71

1.3

0.0018

map00650

Butanoate metabolism

2 of 10

1.65

0.82

0.0229

map00240

Pyrimidine metabolism

3 of 38

1.25

0.75

0.0157

map01120

Microbial metabolism in diverse environments

5 of 141

0.9

0.63

0.0076

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 13

1.71

1.06

0.0069

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

3 of 11

1.79

1.32

0.0020

KW-0560

Oxidoreductase

5 of 62

1.26

1.09

0.00090

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07992

Pyridine nucleotide-disulphide oxidoreductase

3 of 6

2.05

1.4

0.0020

PF14691

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

2 of 2

2.35

0.93

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023753

FAD/NAD(P)-binding domain

3 of 6

2.05

1.18

0.0055

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 12

1.75

0.92

0.0148

IPR036873

Rhodanese-like domain superfamily

2 of 2

2.35

0.78

0.0367

IPR028261

Dihydroprymidine dehydrogenase domain II

2 of 2

2.35

0.78

0.0367

IPR009051

Alpha-helical ferredoxin

2 of 2

2.35

0.78

0.0367

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00450

Rhodanese Homology Domain

2 of 2

2.35

1.09

0.0098

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