node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADA | ADA2 | ENSLAFP00000022424 | ENSLAFP00000018880 | Adenosine deaminase. | Adenosine deaminase 2. | 0.956 |
ADA | IMPDH2 | ENSLAFP00000022424 | ENSLAFP00000010726 | Adenosine deaminase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.504 |
ADA | NT5C | ENSLAFP00000022424 | ENSLAFP00000022269 | Adenosine deaminase. | 5', 3'-nucleotidase, cytosolic. | 0.936 |
ADA | NT5C1A | ENSLAFP00000022424 | ENSLAFP00000027117 | Adenosine deaminase. | 5'-nucleotidase, cytosolic IA. | 0.902 |
ADA | NT5C3A | ENSLAFP00000022424 | ENSLAFP00000004403 | Adenosine deaminase. | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. | 0.906 |
ADA | NT5E | ENSLAFP00000022424 | ENSLAFP00000000205 | Adenosine deaminase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.952 |
ADA | PNP | ENSLAFP00000022424 | ENSLAFP00000003122 | Adenosine deaminase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.982 |
ADA2 | ADA | ENSLAFP00000018880 | ENSLAFP00000022424 | Adenosine deaminase 2. | Adenosine deaminase. | 0.956 |
ADA2 | NT5C | ENSLAFP00000018880 | ENSLAFP00000022269 | Adenosine deaminase 2. | 5', 3'-nucleotidase, cytosolic. | 0.936 |
ADA2 | NT5C1A | ENSLAFP00000018880 | ENSLAFP00000027117 | Adenosine deaminase 2. | 5'-nucleotidase, cytosolic IA. | 0.900 |
ADA2 | NT5C3A | ENSLAFP00000018880 | ENSLAFP00000004403 | Adenosine deaminase 2. | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. | 0.913 |
ADA2 | NT5E | ENSLAFP00000018880 | ENSLAFP00000000205 | Adenosine deaminase 2. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.946 |
ADA2 | PNP | ENSLAFP00000018880 | ENSLAFP00000003122 | Adenosine deaminase 2. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.959 |
GMPR | GMPR2 | ENSLAFP00000012748 | ENSLAFP00000011567 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.969 |
GMPR | IMPDH2 | ENSLAFP00000012748 | ENSLAFP00000010726 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.918 |
GMPR | NT5C | ENSLAFP00000012748 | ENSLAFP00000022269 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5', 3'-nucleotidase, cytosolic. | 0.933 |
GMPR | NT5C1A | ENSLAFP00000012748 | ENSLAFP00000027117 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5'-nucleotidase, cytosolic IA. | 0.912 |
GMPR | NT5C3A | ENSLAFP00000012748 | ENSLAFP00000004403 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. | 0.902 |
GMPR | NT5E | ENSLAFP00000012748 | ENSLAFP00000000205 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.950 |
GMPR | PNP | ENSLAFP00000012748 | ENSLAFP00000003122 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.531 |