node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
G3U095_LOXAF | HGS | ENSLAFP00000021253 | ENSLAFP00000003832 | Uncharacterized protein. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.956 |
G3U095_LOXAF | ITSN2 | ENSLAFP00000021253 | ENSLAFP00000000522 | Uncharacterized protein. | Intersectin 2. | 0.996 |
G3U095_LOXAF | JAK1 | ENSLAFP00000021253 | ENSLAFP00000021176 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.464 |
G3U095_LOXAF | JAK2 | ENSLAFP00000021253 | ENSLAFP00000006285 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.464 |
G3U095_LOXAF | JAK3 | ENSLAFP00000021253 | ENSLAFP00000012874 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.464 |
G3U095_LOXAF | RPS27A | ENSLAFP00000021253 | ENSLAFP00000021261 | Uncharacterized protein. | Ubiquitin-like domain-containing protein. | 0.515 |
G3U095_LOXAF | STAM | ENSLAFP00000021253 | ENSLAFP00000022295 | Uncharacterized protein. | Signal transducing adaptor molecule. | 0.954 |
G3U095_LOXAF | STAM2 | ENSLAFP00000021253 | ENSLAFP00000008249 | Uncharacterized protein. | Signal transducing adaptor molecule 2. | 0.954 |
HGS | G3U095_LOXAF | ENSLAFP00000003832 | ENSLAFP00000021253 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Uncharacterized protein. | 0.956 |
HGS | ITSN2 | ENSLAFP00000003832 | ENSLAFP00000000522 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Intersectin 2. | 0.956 |
HGS | RPS27A | ENSLAFP00000003832 | ENSLAFP00000021261 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Ubiquitin-like domain-containing protein. | 0.881 |
HGS | STAM | ENSLAFP00000003832 | ENSLAFP00000022295 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Signal transducing adaptor molecule. | 0.999 |
HGS | STAM2 | ENSLAFP00000003832 | ENSLAFP00000008249 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Signal transducing adaptor molecule 2. | 0.999 |
HGS | TSG101 | ENSLAFP00000003832 | ENSLAFP00000003068 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Tumor susceptibility 101. | 0.993 |
ITSN2 | G3U095_LOXAF | ENSLAFP00000000522 | ENSLAFP00000021253 | Intersectin 2. | Uncharacterized protein. | 0.996 |
ITSN2 | HGS | ENSLAFP00000000522 | ENSLAFP00000003832 | Intersectin 2. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.956 |
ITSN2 | JAK1 | ENSLAFP00000000522 | ENSLAFP00000021176 | Intersectin 2. | Tyrosine-protein kinase. | 0.464 |
ITSN2 | JAK2 | ENSLAFP00000000522 | ENSLAFP00000006285 | Intersectin 2. | Tyrosine-protein kinase. | 0.464 |
ITSN2 | JAK3 | ENSLAFP00000000522 | ENSLAFP00000012874 | Intersectin 2. | Tyrosine-protein kinase. | 0.464 |
ITSN2 | RPS27A | ENSLAFP00000000522 | ENSLAFP00000021261 | Intersectin 2. | Ubiquitin-like domain-containing protein. | 0.515 |