STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP1BP3Heterochromatin protein 1 binding protein 3. (554 aa)    
Predicted Functional Partners:
KPNB1
Karyopherin subunit beta 1.
    
   0.588
MAP3K6
Mitogen-activated protein kinase kinase kinase 6.
   
  
 0.524
MUL1
Mitochondrial E3 ubiquitin protein ligase 1.
      
 0.517
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.509
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.509
DFFB
DNA fragmentation factor subunit beta.
    
 0.484
SPIN4
Spindlin family member 4.
      
 0.480
TTC9B
Tetratricopeptide repeat domain 9B.
   
 
 0.452
KCNK10
Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.442
LOC111752376
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.433
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.