STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)    
Predicted Functional Partners:
NOD2
Nucleotide binding oligomerization domain containing 2.
   
 0.995
XIAP
X-linked inhibitor of apoptosis.
   
 0.995
NOD1
Nucleotide binding oligomerization domain containing 1.
   
 0.992
NGFR
Nerve growth factor receptor.
    
 0.988
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.977
TAB3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3.
    
 0.969
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.966
CARD6
Caspase recruitment domain family member 6.
    
 0.964
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1.
   
 0.961
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.957
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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