STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)    
Predicted Functional Partners:
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.999
CCND1
Cyclin D1; Belongs to the cyclin family.
   
 0.998
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.998
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.997
CCNA2
Cyclin A2; Belongs to the cyclin family.
    
 0.996
CCNA1
Cyclin A1; Belongs to the cyclin family.
    
 0.994
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.992
SKP2
S-phase kinase associated protein 2.
    
 0.987
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.985
CCND2
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.982
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.