| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL1 | CUL3 | ENSLAFP00000002838 | ENSLAFP00000002647 | Cullin 1; Belongs to the cullin family. | Cullin 3; Belongs to the cullin family. | 0.886 |
| CUL1 | NAE1 | ENSLAFP00000002838 | ENSLAFP00000017677 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.817 |
| CUL1 | NEDD8 | ENSLAFP00000002838 | ENSLAFP00000023296 | Cullin 1; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.990 |
| CUL1 | RBX1 | ENSLAFP00000002838 | ENSLAFP00000007388 | Cullin 1; Belongs to the cullin family. | Ring-box 1. | 0.998 |
| CUL1 | SENP8 | ENSLAFP00000002838 | ENSLAFP00000023445 | Cullin 1; Belongs to the cullin family. | SUMO peptidase family member, NEDD8 specific. | 0.862 |
| CUL1 | UBA3 | ENSLAFP00000002838 | ENSLAFP00000003413 | Cullin 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.920 |
| CUL1 | UBE2F | ENSLAFP00000002838 | ENSLAFP00000011877 | Cullin 1; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.875 |
| CUL1 | UBE2M | ENSLAFP00000002838 | ENSLAFP00000021108 | Cullin 1; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.977 |
| CUL1 | UBXN7 | ENSLAFP00000002838 | ENSLAFP00000026718 | Cullin 1; Belongs to the cullin family. | UBX domain-containing protein 7. | 0.960 |
| CUL3 | CUL1 | ENSLAFP00000002647 | ENSLAFP00000002838 | Cullin 3; Belongs to the cullin family. | Cullin 1; Belongs to the cullin family. | 0.886 |
| CUL3 | NAE1 | ENSLAFP00000002647 | ENSLAFP00000017677 | Cullin 3; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.707 |
| CUL3 | NEDD8 | ENSLAFP00000002647 | ENSLAFP00000023296 | Cullin 3; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.993 |
| CUL3 | RBX1 | ENSLAFP00000002647 | ENSLAFP00000007388 | Cullin 3; Belongs to the cullin family. | Ring-box 1. | 0.998 |
| CUL3 | SENP8 | ENSLAFP00000002647 | ENSLAFP00000023445 | Cullin 3; Belongs to the cullin family. | SUMO peptidase family member, NEDD8 specific. | 0.573 |
| CUL3 | UBA3 | ENSLAFP00000002647 | ENSLAFP00000003413 | Cullin 3; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.863 |
| CUL3 | UBE2F | ENSLAFP00000002647 | ENSLAFP00000011877 | Cullin 3; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.861 |
| CUL3 | UBE2M | ENSLAFP00000002647 | ENSLAFP00000021108 | Cullin 3; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.920 |
| CUL3 | UBXN7 | ENSLAFP00000002647 | ENSLAFP00000026718 | Cullin 3; Belongs to the cullin family. | UBX domain-containing protein 7. | 0.960 |
| NAE1 | CUL1 | ENSLAFP00000017677 | ENSLAFP00000002838 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | Cullin 1; Belongs to the cullin family. | 0.817 |
| NAE1 | CUL3 | ENSLAFP00000017677 | ENSLAFP00000002647 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | Cullin 3; Belongs to the cullin family. | 0.707 |
