G3UAF1_LOXAF protein (Loxodonta africana) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

G3UAF1_LOXAF

Uncharacterized protein. (221 aa)

Predicted Functional Partners:

GAK

0.949

SORCS2

0.900

NGF

0.730

SORT1

0.641

DNAJC6

0.559

NGFR

0.527

VPS35

0.516

CLTC

0.502

IGF2R

0.502

CLHC1

0.462

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLHC1	DNAJC6	ENSLAFP00000029331	ENSLAFP00000019290	Clathrin heavy chain linker domain containing 1.	DnaJ heat shock protein family (Hsp40) member C6.	0.997
CLHC1	G3UAF1_LOXAF	ENSLAFP00000029331	ENSLAFP00000024809	Clathrin heavy chain linker domain containing 1.	Uncharacterized protein.	0.462
CLHC1	GAK	ENSLAFP00000029331	ENSLAFP00000009930	Clathrin heavy chain linker domain containing 1.	Cyclin G associated kinase.	0.999
CLHC1	IGF2R	ENSLAFP00000029331	ENSLAFP00000027769	Clathrin heavy chain linker domain containing 1.	Insulin like growth factor 2 receptor.	0.495
CLHC1	SORCS2	ENSLAFP00000029331	ENSLAFP00000019254	Clathrin heavy chain linker domain containing 1.	Sortilin.	0.462
CLHC1	SORT1	ENSLAFP00000029331	ENSLAFP00000014375	Clathrin heavy chain linker domain containing 1.	Sortilin.	0.462
CLHC1	VPS35	ENSLAFP00000029331	ENSLAFP00000001422	Clathrin heavy chain linker domain containing 1.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.406
CLTC	DNAJC6	ENSLAFP00000008066	ENSLAFP00000019290	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	DnaJ heat shock protein family (Hsp40) member C6.	0.997
CLTC	G3UAF1_LOXAF	ENSLAFP00000008066	ENSLAFP00000024809	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.502
CLTC	GAK	ENSLAFP00000008066	ENSLAFP00000009930	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Cyclin G associated kinase.	0.999
CLTC	IGF2R	ENSLAFP00000008066	ENSLAFP00000027769	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Insulin like growth factor 2 receptor.	0.637
CLTC	SORCS2	ENSLAFP00000008066	ENSLAFP00000019254	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Sortilin.	0.502
CLTC	SORT1	ENSLAFP00000008066	ENSLAFP00000014375	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Sortilin.	0.608
CLTC	VPS35	ENSLAFP00000008066	ENSLAFP00000001422	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.534
DNAJC6	CLHC1	ENSLAFP00000019290	ENSLAFP00000029331	DnaJ heat shock protein family (Hsp40) member C6.	Clathrin heavy chain linker domain containing 1.	0.997
DNAJC6	CLTC	ENSLAFP00000019290	ENSLAFP00000008066	DnaJ heat shock protein family (Hsp40) member C6.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.997
DNAJC6	G3UAF1_LOXAF	ENSLAFP00000019290	ENSLAFP00000024809	DnaJ heat shock protein family (Hsp40) member C6.	Uncharacterized protein.	0.559
DNAJC6	GAK	ENSLAFP00000019290	ENSLAFP00000009930	DnaJ heat shock protein family (Hsp40) member C6.	Cyclin G associated kinase.	0.979
DNAJC6	IGF2R	ENSLAFP00000019290	ENSLAFP00000027769	DnaJ heat shock protein family (Hsp40) member C6.	Insulin like growth factor 2 receptor.	0.957
DNAJC6	SORCS2	ENSLAFP00000019290	ENSLAFP00000019254	DnaJ heat shock protein family (Hsp40) member C6.	Sortilin.	0.559

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006537

Glutamate biosynthetic process

3 of 3

2.35

1.56

0.0012

GO:0044205

De novo UMP biosynthetic process

3 of 9

1.87

1.4

0.0015

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006221

Pyrimidine nucleotide biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

2 of 4

2.05

1.03

0.0113

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

8 of 129

1.14

1.31

5.49e-06

GO:0051536

Iron-sulfur cluster binding

5 of 58

1.29

1.11

0.00099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:666

Ribonucleoside monophosphate biosynthetic process, and Nitrogen metabolism

7 of 36

1.64

2.63

5.16e-08

CL:696

De novo UMP biosynthetic process

3 of 10

1.83

1.39

0.0015

CL:661

Carboxylic acid metabolic process, and Ribonucleoside monophosphate metabolic process

9 of 199

1.01

1.13

1.60e-06

CL:699

De novo UMP biosynthetic process

2 of 5

1.95

0.86

0.0237

CL:718

Nitrogen metabolism

2 of 7

1.81

0.75

0.0364

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.55

1.42

0.00047

map00910

Nitrogen metabolism

3 of 13

1.71

1.3

0.0018

map00650

Butanoate metabolism

2 of 10

1.65

0.82

0.0229

map00240

Pyrimidine metabolism

3 of 38

1.25

0.75

0.0157

map01120

Microbial metabolism in diverse environments

5 of 141

0.9

0.63

0.0076

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 13

1.71

1.06

0.0069

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

3 of 11

1.79

1.32

0.0020

KW-0560

Oxidoreductase

5 of 62

1.26

1.09

0.00090

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07992

Pyridine nucleotide-disulphide oxidoreductase

3 of 6

2.05

1.4

0.0020

PF14691

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

2 of 2

2.35

0.93

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023753

FAD/NAD(P)-binding domain

3 of 6

2.05

1.18

0.0055

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 12

1.75

0.92

0.0148

IPR036873

Rhodanese-like domain superfamily

2 of 2

2.35

0.78

0.0367

IPR028261

Dihydroprymidine dehydrogenase domain II

2 of 2

2.35

0.78

0.0367

IPR009051

Alpha-helical ferredoxin

2 of 2

2.35

0.78

0.0367

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00450

Rhodanese Homology Domain

2 of 2

2.35

1.09

0.0098

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