STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (263 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
   
 0.831
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.831
CHAF1B
Chromatin assembly factor 1 subunit B.
    
 
 0.753
PERP
P53 apoptosis effector related to PMP22.
   
  
 0.726
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.700
GRB14
Growth factor receptor bound protein 14.
      
 0.651
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.631
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.621
NPC1
NPC intracellular cholesterol transporter 1.
   
 0.621
RNF145
Ring finger protein 145.
    
 
 0.610
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.