node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRCA1 | G3U9C8_LOXAF | ENSLAFP00000012177 | ENSLAFP00000024436 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin-like domain-containing protein. | 0.538 |
BRCA1 | G3UBD6_LOXAF | ENSLAFP00000012177 | ENSLAFP00000025144 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | RING-type domain-containing protein. | 0.618 |
BRCA1 | LOC100676713 | ENSLAFP00000012177 | ENSLAFP00000017683 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.625 |
BRCA1 | PIAS4 | ENSLAFP00000012177 | ENSLAFP00000007684 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Protein inhibitor of activated STAT 4. | 0.617 |
BRCA1 | RPS27A | ENSLAFP00000012177 | ENSLAFP00000021261 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin-like domain-containing protein. | 0.538 |
BRCA1 | TP53BP1 | ENSLAFP00000012177 | ENSLAFP00000001013 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Tumor protein p53 binding protein 1. | 0.945 |
BRCA1 | UBA52 | ENSLAFP00000012177 | ENSLAFP00000017811 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.599 |
BRCA1 | UBB | ENSLAFP00000012177 | ENSLAFP00000025209 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin B. | 0.524 |
BRCA1 | UBC | ENSLAFP00000012177 | ENSLAFP00000028641 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Uncharacterized protein. | 0.524 |
BRCA1 | UBE2N | ENSLAFP00000012177 | ENSLAFP00000029473 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.625 |
G3U9C8_LOXAF | BRCA1 | ENSLAFP00000024436 | ENSLAFP00000012177 | Ubiquitin-like domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.538 |
G3U9C8_LOXAF | G3UBD6_LOXAF | ENSLAFP00000024436 | ENSLAFP00000025144 | Ubiquitin-like domain-containing protein. | RING-type domain-containing protein. | 0.660 |
G3U9C8_LOXAF | LOC100676713 | ENSLAFP00000024436 | ENSLAFP00000017683 | Ubiquitin-like domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.845 |
G3U9C8_LOXAF | PIAS4 | ENSLAFP00000024436 | ENSLAFP00000007684 | Ubiquitin-like domain-containing protein. | Protein inhibitor of activated STAT 4. | 0.467 |
G3U9C8_LOXAF | TP53BP1 | ENSLAFP00000024436 | ENSLAFP00000001013 | Ubiquitin-like domain-containing protein. | Tumor protein p53 binding protein 1. | 0.771 |
G3U9C8_LOXAF | UBA52 | ENSLAFP00000024436 | ENSLAFP00000017811 | Ubiquitin-like domain-containing protein. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.987 |
G3U9C8_LOXAF | UBB | ENSLAFP00000024436 | ENSLAFP00000025209 | Ubiquitin-like domain-containing protein. | Ubiquitin B. | 0.813 |
G3U9C8_LOXAF | UBC | ENSLAFP00000024436 | ENSLAFP00000028641 | Ubiquitin-like domain-containing protein. | Uncharacterized protein. | 0.812 |
G3U9C8_LOXAF | UBE2N | ENSLAFP00000024436 | ENSLAFP00000029473 | Ubiquitin-like domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.845 |
G3UBD6_LOXAF | BRCA1 | ENSLAFP00000025144 | ENSLAFP00000012177 | RING-type domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.618 |