STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH2Notch receptor 2. (2446 aa)    
Predicted Functional Partners:
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.989
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.987
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.982
DLL3
Delta like canonical Notch ligand 3.
     
0.968
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.965
MAML2
Mastermind like transcriptional coactivator 2.
    
 0.949
NUMB
NUMB endocytic adaptor protein.
   
 0.939
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.938
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
    
 0.937
APH1A
Aph-1 homolog A, gamma-secretase subunit.
    
 0.936
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.