STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)    
Predicted Functional Partners:
KMT2D
Lysine methyltransferase 2D.
   
 0.660
EFTUD2
Elongation factor Tu GTP binding domain containing 2.
   
 
 0.656
SEMA3E
Semaphorin 3E; Belongs to the semaphorin family.
    
 
 0.620
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
  
 
 
0.619
ARID4B
AT-rich interaction domain 4B.
   
 0.602
ARID4A
AT-rich interaction domain 4A.
   
 0.597
PAICS
AIRC domain-containing protein.
      
 0.582
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 
 0.570
FANCM
FA complementation group M.
    
 0.563
CTNNB1
Catenin beta 1.
    
 0.560
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.