STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (388 aa)    
Predicted Functional Partners:
RTN3
Reticulon.
   
 0.935
RTN4
Reticulon.
   
 0.931
BACE1
Beta-secretase 1; Belongs to the peptidase A1 family.
  
  
 
0.902
APP
Amyloid beta precursor protein.
    
 0.829
NCSTN
Nicastrin.
    
 
 0.720
PSENEN
Uncharacterized protein.
      
 0.587
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding protein 2.
    
 0.569
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.569
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
 0.542
TMEM200A
Transmembrane protein 200A.
      
 0.527
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.