STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHISA6Shisa family member 6. (527 aa)    
Predicted Functional Partners:
GRIN2B
Glutamate ionotropic receptor NMDA type subunit 2B.
     
 0.519
GRIN3A
Glutamate ionotropic receptor NMDA type subunit 3A.
     
 0.508
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
     
 0.483
CACNG3
Calcium voltage-gated channel auxiliary subunit gamma 3.
   
 
 0.464
TXLNB
Taxilin beta.
      
 0.443
DLG3
Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.
     
 0.426
VWC2
Von Willebrand factor C domain containing 2.
     
 0.423
GRIA1
Glutamate ionotropic receptor AMPA type subunit 1.
   
 0.418
CACNG4
Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
 
 0.415
GRIN2D
Glutamate ionotropic receptor NMDA type subunit 2D.
     
 0.405
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.