STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOCS1Suppressor of cytokine signaling 1. (154 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
   
 0.963
ELOB
Elongin B.
    
 0.953
ELOC
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
 0.942
TYK2
Tyrosine-protein kinase.
   
 0.928
JAK1
Tyrosine-protein kinase.
   
 0.895
IFNAR1
Interferon alpha and beta receptor subunit 1.
   
 0.866
CUL5
Cullin 5; Belongs to the cullin family.
   
 0.840
JAK3
Tyrosine-protein kinase.
   
 0.823
CUL2
Cullin 2; Belongs to the cullin family.
   
 0.793
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
 
 0.728
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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