STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD7Mothers against decapentaplegic homolog. (405 aa)    
Predicted Functional Partners:
SMURF1
E3 ubiquitin-protein ligase.
    
 0.988
SMURF2
E3 ubiquitin-protein ligase.
    
 0.984
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
   
 0.980
NEDD4L
E3 ubiquitin-protein ligase.
    
 0.949
RNF111
Ring finger protein 111.
   
 0.902
BAMBI
BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.
   
 0.865
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.842
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
   
 0.803
WWP1
E3 ubiquitin-protein ligase.
    
 0.793
NEDD4
E3 ubiquitin-protein ligase.
    
 0.775
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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