STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (774 aa)    
Predicted Functional Partners:
PSTPIP1
Proline-serine-threonine phosphatase interacting protein 1.
   
 
 0.739
CSK
Tyrosine-protein kinase.
   
 0.692
MATK
Tyrosine-protein kinase.
   
 0.692
ITGA9
Integrin_alpha2 domain-containing protein.
   
 0.624
SHC1
SHC adaptor protein 1.
   
 0.617
SHC3
SHC adaptor protein 3.
   
 0.617
EGFR
Receptor protein-tyrosine kinase.
    
 0.602
LPXN
Leupaxin.
   
 0.551
PXN
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
   
 0.551
ZAP70
Tyrosine-protein kinase.
   
 0.548
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.