STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)    
Predicted Functional Partners:
NTRK2
Tyrosine-protein kinase receptor.
   
 0.993
NGFR
Nerve growth factor receptor.
    
 0.976
NTF4
Neurotrophin 4; Belongs to the NGF-beta family.
    
0.939
NTRK1
Tyrosine-protein kinase receptor.
   
 0.932
NTRK3
Tyrosine-protein kinase receptor.
   
 0.879
NGF
Nerve growth factor; Belongs to the NGF-beta family.
    
0.854
SORT1
Sortilin.
    
 
 0.842
GDNF
Glial cell derived neurotrophic factor.
      
 0.840
IGF1R
Tyrosine-protein kinase receptor.
    
 0.804
NTF3
Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.
  
 
0.748
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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