Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NDNNecdin, MAGE family member. (325 aa)    
Predicted Functional Partners:
NSMCE4A
Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
   
 0.896
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
   
 0.891
EID1
Uncharacterized protein.
   
 
 0.830
SMC6
Structural maintenance of chromosomes 6.
   
 0.797
NSMCE2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
   
 0.796
SMC5
Structural maintenance of chromosomes 5.
   
 0.796
SNRPN
Small nuclear ribonucleoprotein-associated protein.
   
  
 0.790
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.777
NGFR
Nerve growth factor receptor.
    
 0.706
PHLDA2
Pleckstrin homology like domain family A member 2.
   
  
 0.698
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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