Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)    
Predicted Functional Partners:
HCRTR1
Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
 0.982
HCRTR2
Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.979
PMCH
Pro-melanin concentrating hormone.
   
 
 0.978
MCHR2
Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.828
GHRL
Ghrelin and obestatin prepropeptide.
     
 0.828
AGRP
Agouti related neuropeptide.
      
 0.826
NPY
Neuropeptide Y.
      
 0.818
CCK
Cholecystokinin.
   
 
 0.806
POMC
Melanotropin beta; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes; Belongs to the POMC family.
   
  
 0.801
TH
Tyrosine hydroxylase.
   
  
 0.777
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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