Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HMOX1Heme oxygenase 1. (490 aa)    
Predicted Functional Partners:
NFE2L2
Nuclear factor, erythroid 2 like 2.
   
 0.974
BLVRA
Biliverdin reductase A.
   
 
 0.973
BLVRB
Biliverdin reductase B.
    
 0.960
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
    
 0.941
KEAP1
Kelch like ECH associated protein 1.
   
  
 0.918
HEPH
Hephaestin; Belongs to the multicopper oxidase family.
    
 0.912
HMOX2
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
     
 0.911
HEPHL1
Hephaestin like 1; Belongs to the multicopper oxidase family.
    
 0.897
COX10
Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.
     
 0.896
HCCS
Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
     
 0.893
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (14%) [HD]