LOC100070809 protein (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

LOC100070809

Olfactory receptor. (314 aa)

Predicted Functional Partners:

ARRB1

0.701

GNAL

0.701

ARRB2

0.701

GNB1

0.696

GNG13

0.694

GNG7

0.689

GRK3

0.688

GRK2

0.688

GRK3-2

0.688

PRKACA

0.663

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSECAP00000024834	ENSECAP00000045726	Arrestin beta 1.	Arrestin beta 2.	0.909
ARRB1	GRK2	ENSECAP00000024834	ENSECAP00000029787	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.968
ARRB1	GRK3	ENSECAP00000024834	ENSECAP00000017304	Arrestin beta 1.	G protein-coupled receptor kinase 3.	0.905
ARRB1	GRK3-2	ENSECAP00000024834	ENSECAP00000042364	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.891
ARRB1	LOC100070809	ENSECAP00000024834	ENSECAP00000001194	Arrestin beta 1.	Olfactory receptor.	0.701
ARRB1	PRKACA	ENSECAP00000024834	ENSECAP00000030791	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.539
ARRB2	ARRB1	ENSECAP00000045726	ENSECAP00000024834	Arrestin beta 2.	Arrestin beta 1.	0.909
ARRB2	GRK2	ENSECAP00000045726	ENSECAP00000029787	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.966
ARRB2	GRK3	ENSECAP00000045726	ENSECAP00000017304	Arrestin beta 2.	G protein-coupled receptor kinase 3.	0.904
ARRB2	GRK3-2	ENSECAP00000045726	ENSECAP00000042364	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.891
ARRB2	LOC100070809	ENSECAP00000045726	ENSECAP00000001194	Arrestin beta 2.	Olfactory receptor.	0.701
ARRB2	PRKACA	ENSECAP00000045726	ENSECAP00000030791	Arrestin beta 2.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.536
GNAL	GNB1	ENSECAP00000045109	ENSECAP00000044508	G protein subunit alpha L.	G protein subunit beta 1.	0.978
GNAL	GNG13	ENSECAP00000045109	ENSECAP00000015784	G protein subunit alpha L.	G protein subunit gamma 13.	0.978
GNAL	GNG7	ENSECAP00000045109	ENSECAP00000032619	G protein subunit alpha L.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.978
GNAL	LOC100070809	ENSECAP00000045109	ENSECAP00000001194	G protein subunit alpha L.	Olfactory receptor.	0.701
GNB1	GNAL	ENSECAP00000044508	ENSECAP00000045109	G protein subunit beta 1.	G protein subunit alpha L.	0.978
GNB1	GNG13	ENSECAP00000044508	ENSECAP00000015784	G protein subunit beta 1.	G protein subunit gamma 13.	0.985
GNB1	GNG7	ENSECAP00000044508	ENSECAP00000032619	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.977
GNB1	GRK2	ENSECAP00000044508	ENSECAP00000029787	G protein subunit beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.985

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

9

average node degree:

1.8

avg. local clustering coefficient:

0.9

expected number of edges:

9

PPI enrichment p-value:

0.549

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

7 of 17

1.89

3.48

3.32e-09

GO:0009099

Valine biosynthetic process

5 of 8

2.07

2.97

5.78e-07

GO:0009097

Isoleucine biosynthetic process

5 of 10

1.97

2.83

6.93e-07

GO:1901607

Alpha-amino acid biosynthetic process

7 of 59

1.35

1.79

8.69e-07

GO:1901605

Alpha-amino acid metabolic process

8 of 85

1.25

1.62

5.78e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003984

Acetolactate synthase activity

3 of 5

2.05

1.3

0.0032

GO:1990610

Acetolactate synthase regulator activity

2 of 2

2.27

0.85

0.0268

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:844

Valine, leucine and isoleucine biosynthesis, and Phosphopantetheine

9 of 20

1.93

4.8

1.32e-13

CL:845

Valine, leucine and isoleucine biosynthesis

8 of 15

2.0

4.76

1.48e-12

CL:846

Valine metabolic process

7 of 10

2.12

4.73

1.83e-11

CL:848

Valine metabolic process

3 of 5

2.05

1.83

0.00024

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

8 of 15

2.0

4.82

9.46e-13

map01210

2-Oxocarboxylic acid metabolism

7 of 22

1.78

3.39

7.67e-10

map00770

Pantothenate and CoA biosynthesis

5 of 19

1.7

2.35

1.49e-06

map00660

C5-Branched dibasic acid metabolism

4 of 10

1.88

2.35

7.07e-06

map01230

Biosynthesis of amino acids

8 of 94

1.2

1.6

1.27e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

3 of 5

2.05

1.49

0.0013

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 10

1.88

1.97

6.75e-05

KW-0432

Leucine biosynthesis

2 of 5

1.88

0.81

0.0287

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13710

ACT domain

2 of 2

2.27

0.72

0.0483

PF10369

Small subunit of acetolactate synthase

2 of 2

2.27

0.72

0.0483

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