LOC100070809 protein (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC100070809

Olfactory receptor. (314 aa)

Predicted Functional Partners:

ARRB1

0.701

GNAL

0.701

ARRB2

0.701

GNB1

0.696

GNG13

0.694

GNG7

0.689

GRK3

0.688

GRK2

0.688

GRK3-2

0.688

PRKACA

0.663

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSECAP00000024834	ENSECAP00000045726	Arrestin beta 1.	Arrestin beta 2.	0.909
ARRB1	GRK2	ENSECAP00000024834	ENSECAP00000029787	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.968
ARRB1	GRK3	ENSECAP00000024834	ENSECAP00000017304	Arrestin beta 1.	G protein-coupled receptor kinase 3.	0.905
ARRB1	GRK3-2	ENSECAP00000024834	ENSECAP00000042364	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.891
ARRB1	LOC100070809	ENSECAP00000024834	ENSECAP00000001194	Arrestin beta 1.	Olfactory receptor.	0.701
ARRB1	PRKACA	ENSECAP00000024834	ENSECAP00000030791	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.539
ARRB2	ARRB1	ENSECAP00000045726	ENSECAP00000024834	Arrestin beta 2.	Arrestin beta 1.	0.909
ARRB2	GRK2	ENSECAP00000045726	ENSECAP00000029787	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.966
ARRB2	GRK3	ENSECAP00000045726	ENSECAP00000017304	Arrestin beta 2.	G protein-coupled receptor kinase 3.	0.904
ARRB2	GRK3-2	ENSECAP00000045726	ENSECAP00000042364	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.891
ARRB2	LOC100070809	ENSECAP00000045726	ENSECAP00000001194	Arrestin beta 2.	Olfactory receptor.	0.701
ARRB2	PRKACA	ENSECAP00000045726	ENSECAP00000030791	Arrestin beta 2.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.536
GNAL	GNB1	ENSECAP00000045109	ENSECAP00000044508	G protein subunit alpha L.	G protein subunit beta 1.	0.978
GNAL	GNG13	ENSECAP00000045109	ENSECAP00000015784	G protein subunit alpha L.	G protein subunit gamma 13.	0.978
GNAL	GNG7	ENSECAP00000045109	ENSECAP00000032619	G protein subunit alpha L.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.978
GNAL	LOC100070809	ENSECAP00000045109	ENSECAP00000001194	G protein subunit alpha L.	Olfactory receptor.	0.701
GNB1	GNAL	ENSECAP00000044508	ENSECAP00000045109	G protein subunit beta 1.	G protein subunit alpha L.	0.978
GNB1	GNG13	ENSECAP00000044508	ENSECAP00000015784	G protein subunit beta 1.	G protein subunit gamma 13.	0.985
GNB1	GNG7	ENSECAP00000044508	ENSECAP00000032619	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.977
GNB1	GRK2	ENSECAP00000044508	ENSECAP00000029787	G protein subunit beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.985

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235