Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FAM53CFamily with sequence similarity 53 member C. (392 aa)    
Predicted Functional Partners:
DYRK1B
Dual specificity tyrosine phosphorylation regulated kinase 1B.
    
 
 0.954
DYRK1A
Dual specificity tyrosine phosphorylation regulated kinase 1A.
    
 
 0.939
DCAF7
DDB1 and CUL4 associated factor 7.
    
 
 0.892
PLK1
Serine/threonine-protein kinase PLK.
    
 
 0.690
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
    
 
 0.674
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family.
    
 
 0.630
YWHAH
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family.
    
 
 0.630
YWHAE
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.
    
 
 0.603
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family.
    
 
 0.602
YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.
    
 
 0.599
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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