SOCS3 protein (Equus caballus) - STRING interaction network

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Score

SOCS3

Suppressor of cytokine signaling 3. (229 aa)

Predicted Functional Partners:

JAK2

0.999

STAT3

0.992

JAK1

0.988

STAT1

0.984

LEPR

0.983

JAK3

0.983

TYK2

0.973

INSR

0.972

IL6

0.960

STAT5A

0.951

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL6	INSR	ENSECAP00000014219	ENSECAP00000008032	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase receptor.	0.610
IL6	JAK1	ENSECAP00000014219	ENSECAP00000016857	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.974
IL6	JAK2	ENSECAP00000014219	ENSECAP00000008048	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.988
IL6	JAK3	ENSECAP00000014219	ENSECAP00000042461	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.913
IL6	LEPR	ENSECAP00000014219	ENSECAP00000012101	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Leptin receptor.	0.458
IL6	SOCS3	ENSECAP00000014219	ENSECAP00000001322	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Suppressor of cytokine signaling 3.	0.960
IL6	STAT1	ENSECAP00000014219	ENSECAP00000032378	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.925
IL6	STAT3	ENSECAP00000014219	ENSECAP00000036035	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.989
IL6	STAT5A	ENSECAP00000014219	ENSECAP00000039763	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.788
IL6	TYK2	ENSECAP00000014219	ENSECAP00000018211	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.956
INSR	IL6	ENSECAP00000008032	ENSECAP00000014219	Tyrosine-protein kinase receptor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.610
INSR	JAK1	ENSECAP00000008032	ENSECAP00000016857	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.624
INSR	JAK2	ENSECAP00000008032	ENSECAP00000008048	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.838
INSR	JAK3	ENSECAP00000008032	ENSECAP00000042461	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.634
INSR	LEPR	ENSECAP00000008032	ENSECAP00000012101	Tyrosine-protein kinase receptor.	Leptin receptor.	0.713
INSR	SOCS3	ENSECAP00000008032	ENSECAP00000001322	Tyrosine-protein kinase receptor.	Suppressor of cytokine signaling 3.	0.972
INSR	STAT1	ENSECAP00000008032	ENSECAP00000032378	Tyrosine-protein kinase receptor.	Signal transducer and activator of transcription.	0.432
INSR	STAT3	ENSECAP00000008032	ENSECAP00000036035	Tyrosine-protein kinase receptor.	Signal transducer and activator of transcription.	0.705
INSR	STAT5A	ENSECAP00000008032	ENSECAP00000039763	Tyrosine-protein kinase receptor.	Signal transducer and activator of transcription.	0.641
INSR	TYK2	ENSECAP00000008032	ENSECAP00000018211	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.619