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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY3Sprouty RTK signaling antagonist 3. (288 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.718
CBLB
Cbl proto-oncogene B.
    
 0.718
P2RY8
P2Y receptor family member 8; Belongs to the G-protein coupled receptor 1 family.
      
 0.676
PLCXD1
Phosphatidylinositol specific phospholipase C X domain containing 1.
      
 0.632
VAMP7
Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.
      
 0.631
CSRNP1
Cysteine and serine rich nuclear protein 1.
      
 0.604
ZNF536
Zinc finger protein 536.
   
  
 0.590
CHCHD4
Coiled-coil-helix-coiled-coil-helix domain containing 4.
      
 0.570
PPP2R2A
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.
      
 0.570
BEX3
Brain expressed X-linked 3.
      
 0.566
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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