node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHUK | IKBKB | ENSECAP00000036997 | ENSECAP00000030412 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.999 |
CHUK | IL1B | ENSECAP00000036997 | ENSECAP00000053627 | Component of inhibitor of nuclear factor kappa B kinase complex. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | 0.503 |
CHUK | RIPK1 | ENSECAP00000036997 | ENSECAP00000008268 | Component of inhibitor of nuclear factor kappa B kinase complex. | Receptor interacting serine/threonine kinase 1. | 0.974 |
CHUK | TBK1 | ENSECAP00000036997 | ENSECAP00000018587 | Component of inhibitor of nuclear factor kappa B kinase complex. | TANK binding kinase 1. | 0.728 |
CHUK | TNF | ENSECAP00000036997 | ENSECAP00000001460 | Component of inhibitor of nuclear factor kappa B kinase complex. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.980 |
CHUK | TNFAIP3 | ENSECAP00000036997 | ENSECAP00000007693 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNF alpha induced protein 3. | 0.640 |
CHUK | TNFRSF1A | ENSECAP00000036997 | ENSECAP00000054554 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNF receptor superfamily member 1A. | 0.978 |
CHUK | TRADD | ENSECAP00000036997 | ENSECAP00000011430 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNFRSF1A associated via death domain. | 0.979 |
IKBKB | CHUK | ENSECAP00000030412 | ENSECAP00000036997 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.999 |
IKBKB | IL1B | ENSECAP00000030412 | ENSECAP00000053627 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | 0.508 |
IKBKB | RIPK1 | ENSECAP00000030412 | ENSECAP00000008268 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Receptor interacting serine/threonine kinase 1. | 0.965 |
IKBKB | RIPK3 | ENSECAP00000030412 | ENSECAP00000006806 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Receptor interacting serine/threonine kinase 3. | 0.402 |
IKBKB | TBK1 | ENSECAP00000030412 | ENSECAP00000018587 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TANK binding kinase 1. | 0.531 |
IKBKB | TNF | ENSECAP00000030412 | ENSECAP00000001460 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.980 |
IKBKB | TNFAIP3 | ENSECAP00000030412 | ENSECAP00000007693 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TNF alpha induced protein 3. | 0.702 |
IKBKB | TNFRSF1A | ENSECAP00000030412 | ENSECAP00000054554 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TNF receptor superfamily member 1A. | 0.997 |
IKBKB | TRADD | ENSECAP00000030412 | ENSECAP00000011430 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TNFRSF1A associated via death domain. | 0.975 |
IL1B | CHUK | ENSECAP00000053627 | ENSECAP00000036997 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.503 |
IL1B | IKBKB | ENSECAP00000053627 | ENSECAP00000030412 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.508 |
IL1B | RIPK1 | ENSECAP00000053627 | ENSECAP00000008268 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | Receptor interacting serine/threonine kinase 1. | 0.439 |