Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)    
Predicted Functional Partners:
HRG
Histidine rich glycoprotein.
   
 0.624
SERPIND1
Serpin family D member 1; Belongs to the serpin family.
   
 0.598
SERPING1
Serpin family G member 1; Belongs to the serpin family.
   
 0.591
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
  
0.582
F12
Coagulation factor XII.
  
0.575
F8
Coagulation factor VIII; Belongs to the multicopper oxidase family.
   
 0.574
TMPRSS4
Transmembrane serine protease 4; Belongs to the peptidase S1 family.
  
0.572
HGFAC
HGF activator.
  
0.567
KNG1
Kininogen 1.
   
 0.550
PRCC
Proline rich mitotic checkpoint control factor.
    
   0.546
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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