STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)    
Predicted Functional Partners:
F9
Coagulation factor IX.
  
0.956
F12
Coagulation factor XII.
  
0.945
SERPINC1
Serpin family C member 1; Belongs to the serpin family.
   
 0.926
AMBP
Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.
   
 0.648
HRG
Histidine rich glycoprotein.
   
 0.627
SERPING1
Serpin family G member 1; Belongs to the serpin family.
   
 0.609
APP
Amyloid beta precursor protein.
    
 0.594
KNG1
Kininogen 1.
   
 0.592
F13B
Coagulation factor XIII B chain.
   
 0.527
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
  
0.508
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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