Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DNAJC22DnaJ heat shock protein family (Hsp40) member C22. (341 aa)    
Predicted Functional Partners:
HSPA9
Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.
  
 0.642
HSPA5
Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.
  
 0.538
ANKRD45
Ankyrin repeat domain 45.
  
 0.538
NME8
NME/NM23 family member 8.
   
 0.538
DNAJA2
DnaJ heat shock protein family (Hsp40) member A2.
   
 0.536
HSPH1
Heat shock protein family H (Hsp110) member 1.
  
 0.527
HSPA4
Heat shock protein family A (Hsp70) member 4.
  
 0.527
HSPA4L
Heat shock protein family A (Hsp70) member 4 like.
  
 0.527
HSP90AB1
Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]
  
 0.517
TSC1
TSC complex subunit 1.
  
 0.517
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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