ASIP protein (Equus caballus) - STRING interaction network

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ASIP

Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (133 aa)

Predicted Functional Partners:

TYRP1

0.870

AHCY

0.850

MITF

0.778

TYR

0.777

STX17

0.770

KIT

0.710

EDN3

0.706

OCA2

0.704

LOC111771889

0.664

RALY

0.664

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCY	ASIP	ENSECAP00000018316	ENSECAP00000003317	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.850
AHCY	LOC111771889	ENSECAP00000018316	ENSECAP00000023921	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	RALY heterogeneous nuclear ribonucleoprotein.	0.726
AHCY	RALY	ENSECAP00000018316	ENSECAP00000038008	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	RALY heterogeneous nuclear ribonucleoprotein.	0.727
ASIP	AHCY	ENSECAP00000003317	ENSECAP00000018316	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	0.850
ASIP	EDN3	ENSECAP00000003317	ENSECAP00000004408	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Endothelin 3.	0.706
ASIP	KIT	ENSECAP00000003317	ENSECAP00000011188	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.710
ASIP	LOC111771889	ENSECAP00000003317	ENSECAP00000023921	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	RALY heterogeneous nuclear ribonucleoprotein.	0.664
ASIP	MITF	ENSECAP00000003317	ENSECAP00000051097	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Melanocyte inducing transcription factor.	0.778
ASIP	OCA2	ENSECAP00000003317	ENSECAP00000032264	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	OCA2 melanosomal transmembrane protein.	0.704
ASIP	RALY	ENSECAP00000003317	ENSECAP00000038008	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	RALY heterogeneous nuclear ribonucleoprotein.	0.664
ASIP	STX17	ENSECAP00000003317	ENSECAP00000012871	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Syntaxin 17; Belongs to the syntaxin family.	0.770
ASIP	TYR	ENSECAP00000003317	ENSECAP00000014187	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Tyrosinase.	0.777
ASIP	TYRP1	ENSECAP00000003317	ENSECAP00000007884	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Tyrosinase related protein 1.	0.870
EDN3	ASIP	ENSECAP00000004408	ENSECAP00000003317	Endothelin 3.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.706
EDN3	KIT	ENSECAP00000004408	ENSECAP00000011188	Endothelin 3.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.637
EDN3	MITF	ENSECAP00000004408	ENSECAP00000051097	Endothelin 3.	Melanocyte inducing transcription factor.	0.695
EDN3	TYR	ENSECAP00000004408	ENSECAP00000014187	Endothelin 3.	Tyrosinase.	0.662
EDN3	TYRP1	ENSECAP00000004408	ENSECAP00000007884	Endothelin 3.	Tyrosinase related protein 1.	0.614
KIT	ASIP	ENSECAP00000011188	ENSECAP00000003317	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.710
KIT	EDN3	ENSECAP00000011188	ENSECAP00000004408	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Endothelin 3.	0.637

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