node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD34 | CSF3 | ENSECAP00000022541 | ENSECAP00000006754 | CD34 molecule. | Colony stimulating factor 3. | 0.835 |
CD34 | EPO | ENSECAP00000022541 | ENSECAP00000037030 | CD34 molecule. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.728 |
CD34 | EPOR | ENSECAP00000022541 | ENSECAP00000006353 | CD34 molecule. | Erythropoietin receptor; Receptor for erythropoietin. | 0.439 |
CD34 | KITLG | ENSECAP00000022541 | ENSECAP00000000163 | CD34 molecule. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.864 |
CD34 | LEP | ENSECAP00000022541 | ENSECAP00000035337 | CD34 molecule. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.455 |
CD34 | MPL | ENSECAP00000022541 | ENSECAP00000014725 | CD34 molecule. | MPL proto-oncogene, thrombopoietin receptor. | 0.484 |
CD34 | THPO | ENSECAP00000022541 | ENSECAP00000004295 | CD34 molecule. | Thrombopoietin. | 0.853 |
CSF3 | CD34 | ENSECAP00000006754 | ENSECAP00000022541 | Colony stimulating factor 3. | CD34 molecule. | 0.835 |
CSF3 | CSF3R | ENSECAP00000006754 | ENSECAP00000011394 | Colony stimulating factor 3. | Colony stimulating factor 3 receptor. | 0.998 |
CSF3 | EPO | ENSECAP00000006754 | ENSECAP00000037030 | Colony stimulating factor 3. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.749 |
CSF3 | EPOR | ENSECAP00000006754 | ENSECAP00000006353 | Colony stimulating factor 3. | Erythropoietin receptor; Receptor for erythropoietin. | 0.718 |
CSF3 | GH1 | ENSECAP00000006754 | ENSECAP00000007142 | Colony stimulating factor 3. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.903 |
CSF3 | KITLG | ENSECAP00000006754 | ENSECAP00000000163 | Colony stimulating factor 3. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.740 |
CSF3 | LEP | ENSECAP00000006754 | ENSECAP00000035337 | Colony stimulating factor 3. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.943 |
CSF3 | MPL | ENSECAP00000006754 | ENSECAP00000014725 | Colony stimulating factor 3. | MPL proto-oncogene, thrombopoietin receptor. | 0.797 |
CSF3 | PRL | ENSECAP00000006754 | ENSECAP00000000120 | Colony stimulating factor 3. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.905 |
CSF3 | THPO | ENSECAP00000006754 | ENSECAP00000004295 | Colony stimulating factor 3. | Thrombopoietin. | 0.976 |
CSF3R | CSF3 | ENSECAP00000011394 | ENSECAP00000006754 | Colony stimulating factor 3 receptor. | Colony stimulating factor 3. | 0.998 |
CSF3R | GH1 | ENSECAP00000011394 | ENSECAP00000007142 | Colony stimulating factor 3 receptor. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.650 |
CSF3R | LEP | ENSECAP00000011394 | ENSECAP00000035337 | Colony stimulating factor 3 receptor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.652 |