RDH10 protein (Equus caballus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

RDH10

Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)

Predicted Functional Partners:

CYP26A1

0.973

RDH11

0.969

LRAT

0.960

RPE65

0.958

RDH5

0.937

BCO1

0.932

DGAT1

0.931

ALDH1A2

0.930

RLBP1

0.926

CYP27C1

0.921

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	BCO1	ENSECAP00000012983	ENSECAP00000000324	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Beta-carotene oxygenase 1.	0.921
ALDH1A2	CYP26A1	ENSECAP00000012983	ENSECAP00000019834	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	0.964
ALDH1A2	RDH10	ENSECAP00000012983	ENSECAP00000004322	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.930
ALDH1A2	RDH11	ENSECAP00000012983	ENSECAP00000018220	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.939
ALDH1A2	RDH5	ENSECAP00000012983	ENSECAP00000017236	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.906
BCO1	ALDH1A2	ENSECAP00000000324	ENSECAP00000012983	Beta-carotene oxygenase 1.	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	0.921
BCO1	LRAT	ENSECAP00000000324	ENSECAP00000025254	Beta-carotene oxygenase 1.	Lecithin retinol acyltransferase.	0.581
BCO1	RDH10	ENSECAP00000000324	ENSECAP00000004322	Beta-carotene oxygenase 1.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.932
BCO1	RDH11	ENSECAP00000000324	ENSECAP00000018220	Beta-carotene oxygenase 1.	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.911
CYP26A1	ALDH1A2	ENSECAP00000019834	ENSECAP00000012983	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	0.964
CYP26A1	CYP27C1	ENSECAP00000019834	ENSECAP00000015112	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.926
CYP26A1	DGAT1	ENSECAP00000019834	ENSECAP00000013126	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	O-acyltransferase.	0.931
CYP26A1	LRAT	ENSECAP00000019834	ENSECAP00000025254	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Lecithin retinol acyltransferase.	0.948
CYP26A1	RDH10	ENSECAP00000019834	ENSECAP00000004322	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.973
CYP26A1	RDH11	ENSECAP00000019834	ENSECAP00000018220	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.935
CYP27C1	CYP26A1	ENSECAP00000015112	ENSECAP00000019834	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	0.926
CYP27C1	DGAT1	ENSECAP00000015112	ENSECAP00000013126	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	O-acyltransferase.	0.905
CYP27C1	LRAT	ENSECAP00000015112	ENSECAP00000025254	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Lecithin retinol acyltransferase.	0.907
CYP27C1	RDH10	ENSECAP00000015112	ENSECAP00000004322	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.921
CYP27C1	RDH11	ENSECAP00000015112	ENSECAP00000018220	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.916

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.803

expected number of edges:

14

PPI enrichment p-value:

1.95e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007601

Visual perception

5 of 105

1.9

2.16

2.51e-05

GO:0051606

Detection of stimulus

5 of 202

1.62

1.69

0.00010

GO:0007602

Phototransduction

3 of 28

2.25

1.69

0.00063

GO:0007603

Phototransduction, visible light

2 of 4

2.92

1.39

0.0030

GO:0001580

Detection of chemical stimulus involved in sensory perception of bitter taste

2 of 5

2.82

1.33

0.0039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004703

G protein-coupled receptor kinase activity

3 of 8

2.8

2.28

6.64e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 34

2.39

3.91

1.89e-08

GO:0001750

Photoreceptor outer segment

4 of 49

2.13

2.69

3.57e-06

GO:0001917

Photoreceptor inner segment

3 of 36

2.14

1.97

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25806532

(2015) Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.

5 of 7

3.08

5.85

1.60e-11

PMID:29321241

(2018) Evolution of the shut-off steps of vertebrate phototransduction.

3 of 5

3.0

3.41e-06

PMID:27296292

(2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity.

3 of 7

2.85

2.89

4.87e-06

PMID:35412676

(2022) Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.

3 of 11

2.66

2.67

1.11e-05

PMID:30257895

(2018) Evolution of the calcium feedback steps of vertebrate phototransduction.

3 of 11

2.66

2.67

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27653

Rhodopsin, and GPCR kinase

6 of 11

2.96

6.77

2.08e-13

CL:27402

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

11 of 172

2.03

6.6

2.76e-19

CL:27656

Methylation, and Vision

4 of 5

3.13

4.58

4.24e-09

CL:27492

Sensory perception of bitter taste, and Retinal cGMP phosphodiesterase, gamma subunit

4 of 5

3.13

4.58

4.24e-09

CL:27427

GTPase complex, and Prostanoid receptor

5 of 39

2.33

3.96

1.11e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04744

Phototransduction

10 of 39

2.63

10.84

1.47e-23

map04371

Apelin signaling pathway

3 of 144

1.54

0.98

0.0077

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2514856

The phototransduction cascade

9 of 42

2.55

8.78

4.24e-19

MAP-2514859

Inactivation, recovery and regulation of the phototransduction cascade

8 of 41

2.51

7.57

1.92e-16

MAP-2187338

Visual phototransduction

9 of 118

2.1

6.06

8.18e-16

MAP-9709957

Sensory Perception

10 of 264

1.8

4.65

2.10e-15

MAP-2485179

Activation of the phototransduction cascade

4 of 16

2.62

3.68

1.11e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 10491

0.24

0.23

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0001917

Photoreceptor inner segment

4 of 22

2.48

3.05

1.55e-06

GOCC:0005834

Heterotrimeric G-protein complex

3 of 10

2.7

2.42

3.41e-05

GOCC:0001750

Photoreceptor outer segment

2 of 38

1.94

0.76

0.0376

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0488

Methylation

2 of 2

3.22

1.77

0.00064

KW-0723

Serine/threonine-protein kinase

3 of 194

1.41

0.73

0.0270

KW-0807

Transducer

4 of 569

1.07

0.61

0.0270

KW-0547

Nucleotide-binding

5 of 993

0.92

0.54

0.0270

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000239

GPCR kinase

3 of 8

2.8

2.06

0.00017

IPR044926

RGS, subdomain 2

3 of 38

2.12

1.21

0.0052

IPR036305

RGS domain superfamily

3 of 38

2.12

1.21

0.0052

IPR016137

RGS domain

3 of 37

2.13

1.21

0.0052

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 5

2.82

1.17

0.0075

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00315

Regulator of G protein signalling domain

3 of 32

2.19

1.63

0.00078

SM00133

Extension to Ser/Thr-type protein kinases

3 of 54

1.97

1.41

0.0017

SM00275

G protein alpha subunit

2 of 15

2.35

1.06

0.0111

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