STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
   
 0.808
RNF145
Ring finger protein 145.
    
 
 0.801
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.795
MORC3
MORC family CW-type zinc finger 3.
    
 
 0.688
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.663
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.649
AMFR
Autocrine motility factor receptor.
   
 
 0.648
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
  
 0.633
UBIAD1
UbiA prenyltransferase domain containing 1.
      
 0.632
TMEM19
Transmembrane protein 19.
      
 0.623
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.