STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMCO1Single-pass membrane protein with coiled-coil domains 1. (214 aa)    
Predicted Functional Partners:
UBXN7
UBX domain protein 7.
   
  
 0.698
PCYT1A
Phosphate cytidylyltransferase 1, choline, alpha.
   
  
 0.668
CEP19
Centrosomal protein 19.
   
  
 0.584
SLC51A
Solute carrier family 51 alpha subunit.
      
 0.577
TM4SF19
Uncharacterized protein.
      
 0.574
WDR53
WD repeat domain 53.
   
  
 0.565
TCTEX1D2
Uncharacterized protein.
   
  
 0.564
RNF168
E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]
 
 
  
 0.557
MAPK8IP3
Mitogen-activated protein kinase 8 interacting protein 3.
   
   0.504
FBXO45
F-box protein 45.
   
  
 0.499
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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