FAM53B protein (Equus caballus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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[Homology]

Score

FAM53B

Family with sequence similarity 53 member B. (425 aa)

Predicted Functional Partners:

CYFIP2

0.688

GLO1

0.660

CNIH3

0.629

CNIH2

0.629

DIP2C

0.558

RUFY1

0.485

HNRNPH1

0.479

HNRNPH2

0.479

RBM4B

0.476

ANKRD54

0.476

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD54	FAM53B	ENSECAP00000030573	ENSECAP00000005862	Ankyrin repeat domain 54.	Family with sequence similarity 53 member B.	0.476
CNIH2	FAM53B	ENSECAP00000034933	ENSECAP00000005862	Cornichon family AMPA receptor auxiliary protein 2.	Family with sequence similarity 53 member B.	0.629
CNIH2	GLO1	ENSECAP00000034933	ENSECAP00000017243	Cornichon family AMPA receptor auxiliary protein 2.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.494
CNIH2	RUFY1	ENSECAP00000034933	ENSECAP00000040689	Cornichon family AMPA receptor auxiliary protein 2.	RUN and FYVE domain containing 1.	0.475
CNIH3	FAM53B	ENSECAP00000016706	ENSECAP00000005862	Cornichon family AMPA receptor auxiliary protein 3.	Family with sequence similarity 53 member B.	0.629
CNIH3	GLO1	ENSECAP00000016706	ENSECAP00000017243	Cornichon family AMPA receptor auxiliary protein 3.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.494
CNIH3	RUFY1	ENSECAP00000016706	ENSECAP00000040689	Cornichon family AMPA receptor auxiliary protein 3.	RUN and FYVE domain containing 1.	0.475
CYFIP2	FAM53B	ENSECAP00000033790	ENSECAP00000005862	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Family with sequence similarity 53 member B.	0.688
DIP2C	FAM53B	ENSECAP00000007450	ENSECAP00000005862	Disco interacting protein 2 homolog C.	Family with sequence similarity 53 member B.	0.558
FAM53B	ANKRD54	ENSECAP00000005862	ENSECAP00000030573	Family with sequence similarity 53 member B.	Ankyrin repeat domain 54.	0.476
FAM53B	CNIH2	ENSECAP00000005862	ENSECAP00000034933	Family with sequence similarity 53 member B.	Cornichon family AMPA receptor auxiliary protein 2.	0.629
FAM53B	CNIH3	ENSECAP00000005862	ENSECAP00000016706	Family with sequence similarity 53 member B.	Cornichon family AMPA receptor auxiliary protein 3.	0.629
FAM53B	CYFIP2	ENSECAP00000005862	ENSECAP00000033790	Family with sequence similarity 53 member B.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.688
FAM53B	DIP2C	ENSECAP00000005862	ENSECAP00000007450	Family with sequence similarity 53 member B.	Disco interacting protein 2 homolog C.	0.558
FAM53B	GLO1	ENSECAP00000005862	ENSECAP00000017243	Family with sequence similarity 53 member B.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.660
FAM53B	HNRNPH1	ENSECAP00000005862	ENSECAP00000012462	Family with sequence similarity 53 member B.	Heterogeneous nuclear ribonucleoprotein H1.	0.479
FAM53B	HNRNPH2	ENSECAP00000005862	ENSECAP00000020981	Family with sequence similarity 53 member B.	Heterogeneous nuclear ribonucleoprotein H2.	0.479
FAM53B	RBM4B	ENSECAP00000005862	ENSECAP00000020394	Family with sequence similarity 53 member B.	RNA binding motif protein 4B.	0.476
FAM53B	RUFY1	ENSECAP00000005862	ENSECAP00000040689	Family with sequence similarity 53 member B.	RUN and FYVE domain containing 1.	0.485
GLO1	CNIH2	ENSECAP00000017243	ENSECAP00000034933	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	Cornichon family AMPA receptor auxiliary protein 2.	0.494

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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