STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1886 aa)    
Predicted Functional Partners:
GPIHBP1
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1.
     
 0.869
SCG5
Secretogranin V.
   
 
 0.756
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
   
 
  0.727
LIPG
Lipase G, endothelial type.
   
 0.712
MBTPS1
Membrane bound transcription factor peptidase, site 1.
      
 0.679
ALX3
ALX homeobox 3.
    
 
 0.643
GDF11
Growth differentiation factor 11.
   
 0.595
ASPH
Aspartate beta-hydroxylase.
    
 
 0.567
WIPF1
WAS/WASL interacting protein family member 1.
      
 0.567
SYT6
Synaptotagmin 6.
   
  
 0.562
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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