node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPO | EPOR | ENSECAP00000037030 | ENSECAP00000006353 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Erythropoietin receptor; Receptor for erythropoietin. | 0.994 |
EPO | JAK1 | ENSECAP00000037030 | ENSECAP00000016857 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.434 |
EPO | JAK2 | ENSECAP00000037030 | ENSECAP00000008048 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.876 |
EPO | JAK3 | ENSECAP00000037030 | ENSECAP00000042461 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.510 |
EPO | LEP | ENSECAP00000037030 | ENSECAP00000035337 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.600 |
EPO | LYN | ENSECAP00000037030 | ENSECAP00000042138 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.577 |
EPO | TFR2 | ENSECAP00000037030 | ENSECAP00000022296 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Transferrin receptor 2. | 0.447 |
EPO | TFRC | ENSECAP00000037030 | ENSECAP00000021947 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). | 0.638 |
EPO | THPO | ENSECAP00000037030 | ENSECAP00000004295 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Thrombopoietin. | 0.814 |
EPO | TYK2 | ENSECAP00000037030 | ENSECAP00000018211 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.465 |
EPOR | EPO | ENSECAP00000006353 | ENSECAP00000037030 | Erythropoietin receptor; Receptor for erythropoietin. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.994 |
EPOR | JAK1 | ENSECAP00000006353 | ENSECAP00000016857 | Erythropoietin receptor; Receptor for erythropoietin. | Tyrosine-protein kinase. | 0.959 |
EPOR | JAK2 | ENSECAP00000006353 | ENSECAP00000008048 | Erythropoietin receptor; Receptor for erythropoietin. | Tyrosine-protein kinase. | 0.999 |
EPOR | JAK3 | ENSECAP00000006353 | ENSECAP00000042461 | Erythropoietin receptor; Receptor for erythropoietin. | Tyrosine-protein kinase. | 0.972 |
EPOR | LEP | ENSECAP00000006353 | ENSECAP00000035337 | Erythropoietin receptor; Receptor for erythropoietin. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.850 |
EPOR | LYN | ENSECAP00000006353 | ENSECAP00000042138 | Erythropoietin receptor; Receptor for erythropoietin. | Tyrosine-protein kinase. | 0.952 |
EPOR | TFR2 | ENSECAP00000006353 | ENSECAP00000022296 | Erythropoietin receptor; Receptor for erythropoietin. | Transferrin receptor 2. | 0.923 |
EPOR | TFRC | ENSECAP00000006353 | ENSECAP00000021947 | Erythropoietin receptor; Receptor for erythropoietin. | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). | 0.888 |
EPOR | THPO | ENSECAP00000006353 | ENSECAP00000004295 | Erythropoietin receptor; Receptor for erythropoietin. | Thrombopoietin. | 0.817 |
EPOR | TYK2 | ENSECAP00000006353 | ENSECAP00000018211 | Erythropoietin receptor; Receptor for erythropoietin. | Tyrosine-protein kinase. | 0.918 |