GZMK protein (Equus caballus) - STRING interaction network

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Score

GZMK

Granzyme K; Belongs to the peptidase S1 family. (264 aa)

Predicted Functional Partners:

CFB

0.722

CD3D

0.704

NKG7

0.672

GNLY

0.655

ADIPOQ

0.615

EOMES

0.606

CCL5

0.580

CD3E

0.539

CCR7

0.524

KLRD1

0.520

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	GZMK	ENSECAP00000002024	ENSECAP00000006656	Adiponectin, C1Q and collagen domain containing.	Granzyme K; Belongs to the peptidase S1 family.	0.615
CCL5	CCR7	ENSECAP00000022430	ENSECAP00000003375	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.958
CCL5	CD3D	ENSECAP00000022430	ENSECAP00000015856	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	CD3d molecule.	0.651
CCL5	CD3E	ENSECAP00000022430	ENSECAP00000031649	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	CD3e molecule.	0.489
CCL5	GNLY	ENSECAP00000022430	ENSECAP00000031488	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).	0.517
CCL5	GZMK	ENSECAP00000022430	ENSECAP00000006656	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Granzyme K; Belongs to the peptidase S1 family.	0.580
CCL5	KLRD1	ENSECAP00000022430	ENSECAP00000036098	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-type lectin domain-containing protein.	0.480
CCL5	NKG7	ENSECAP00000022430	ENSECAP00000011861	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Natural killer cell granule protein 7.	0.785
CCR7	CCL5	ENSECAP00000003375	ENSECAP00000022430	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.958
CCR7	CD3D	ENSECAP00000003375	ENSECAP00000015856	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3d molecule.	0.634
CCR7	CD3E	ENSECAP00000003375	ENSECAP00000031649	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3e molecule.	0.627
CCR7	EOMES	ENSECAP00000003375	ENSECAP00000018617	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Eomesodermin.	0.579
CCR7	GZMK	ENSECAP00000003375	ENSECAP00000006656	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Granzyme K; Belongs to the peptidase S1 family.	0.524
CCR7	KLRD1	ENSECAP00000003375	ENSECAP00000036098	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-type lectin domain-containing protein.	0.420
CCR7	NKG7	ENSECAP00000003375	ENSECAP00000011861	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Natural killer cell granule protein 7.	0.570
CD3D	CCL5	ENSECAP00000015856	ENSECAP00000022430	CD3d molecule.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.651
CD3D	CCR7	ENSECAP00000015856	ENSECAP00000003375	CD3d molecule.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.634
CD3D	CD3E	ENSECAP00000015856	ENSECAP00000031649	CD3d molecule.	CD3e molecule.	0.999
CD3D	GNLY	ENSECAP00000015856	ENSECAP00000031488	CD3d molecule.	Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).	0.608
CD3D	GZMK	ENSECAP00000015856	ENSECAP00000006656	CD3d molecule.	Granzyme K; Belongs to the peptidase S1 family.	0.704