STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB2Damage specific DNA binding protein 2. (427 aa)    
Predicted Functional Partners:
DDB1
Damage specific DNA binding protein 1.
    
 0.999
CUL4A
Cullin 4A; Belongs to the cullin family.
    
 0.990
USP24
Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.
    
 0.983
RBX1
Ring-box 1.
    
 0.978
XPA
XPA, DNA damage recognition and repair factor.
   
 0.971
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 0.971
COP1
COP1 E3 ubiquitin ligase.
    
 0.968
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
   
0.965
DCAF5
DDB1 and CUL4 associated factor 5.
     
 0.942
DET1
DET1 partner of COP1 E3 ubiquitin ligase.
   
 
 0.942
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.